anti-Complement Factor H-Related 5 (CFHR5) Anticorps

CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. De plus, nous expédions Complement Factor H-Related 5 Protéines (7) et Complement Factor H-Related 5 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CFHR5 81494 Q9BXR6
CFHR5    
CFHR5    
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Top anti-Complement Factor H-Related 5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 45 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-CFHR5 Antibody Titration: 1.0 ug/ml Positive Control: THP-1 Whole Cell 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis in CEM(lane 1),K562(lane 2) cell line lysates (15ug/lane). CFHR5 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Détails
Humain Souris Inconjugué Fig. 1. Figure 1:Black line: Control Antigen (100 ng)Purple line: Antigen (10ng) 100 μg 11 to 16 Days
$469.05
Détails
Humain Lapin Inconjugué WB Western Blot analysis of CFHR5 expression in transfected 293T cell line by CFHR5 MaxPab polyclonal antibody.Lane 1: CFHR5 transfected lysate(64.40 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Détails
Humain Lapin Inconjugué IP, WB Immunoprecipitation of CFHR5 transfected lysate using anti-CFHR5 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with CFHL5 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of CFHR5 expression in transfected 293T cell line by CFHR5 MaxPab polyclonal antibody.Lane 1: CFHR5 transfected lysate(64.40 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Détails
Humain Souris Inconjugué ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CFHR5 mAb against human CFHR5 (AA: 344-569) recombinant protein. (Expected MW is 51.8 kDa) 0.1 mg 3 to 4 Days
$430.10
Détails
Humain Souris Inconjugué ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CFHR5 mAb against human CFHR5 (AA: 344-569) recombinant protein. (Expected MW is 51.8 kDa) 0.1 mg 3 to 4 Days
$430.10
Détails
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
$551.83
Détails
Humain Souris Inconjugué IP, ELISA, WB   100 μg 11 to 14 Days
$969.83
Détails
Humain Souris Inconjugué WB Western Blot analysis of CFHR5 expression in transfected 293T cell line by CFHR5 MaxPab polyclonal antibody.Lane 1: CFHL5 transfected lysate(62.59 KDa).Lane 2: Non-transfected lysate. CFHR5 MaxPab polyclonal antibody. Western Blot analysis of CFHR5 expression in human kidney. 50 μg 11 to 12 Days
$440.00
Détails

anti-Complement Factor H-Related 5 Anticorps mieux référencés

  1. Human Polyclonal CFHR5 Primary Antibody pour WB - ABIN529341 : Medjeral-Thomas, Malik, Patel, Toth, Cook, Tomson, Pickering: A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestry. dans Kidney international 2014 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Complement Factor H-Related 5 partenaires d’interaction

Human Complement Factor H-Related 5 (CFHR5) interaction partners

  1. Higher circulating FHR-5 levels in IgA nephropathy patients were associated with a lower estimated glomerular filtration rate, hypertension, and severe Oxford-T and Oxford-C scores. High FHR-5 levels were independently and significantly associated with a risk of developing either a 30% decline in the estimated glomerular filtration rate or end-stage renal disease.

  2. Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp involving multiple CFHR genes leading to a CFHR1-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy.

  3. Higher serum FHR-5 levels were associated with a lack of response to immunosuppression, the presence of endocapillary hypercellularity, and histology scores of IgA nephropathy severity.

  4. Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene

  5. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR5]

  6. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  7. In this study, we identify pentraxin 3 (PTX3) as a novel ligand of CFHR5

  8. At least two distinct intronic breakpoints within the CFHR5 gene can cause the same mutant CFHR5 protein and C3 glomerulopathy.

  9. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay.

  10. Recent investigations in London and Cyprus culminated in the identification of another autosomal dominant condition that presents with microscopic haematuria because of heterozygous mutations in the CFHR5 gene--{review}

  11. A potentially pathogenic sequence variation was found in CFHR5 in the patients with atypical hemolytic uremic syndrome.

  12. CFHR5 nephropathy is discussed.

  13. Describe the clinical course, significant variable expressivity, and marked gender difference regarding the development of chronic renal failure in familial C3 glomerulopathy associated with CFHR5 mutations.

  14. evidence for an inherited renal disease, endemic in Cyprus, characterised by microscopic and synpharyngitic macroscopic haematuria, renal failure and C3 glomerulonephritis; affected individuals have an internal duplication within the gene for CFHR5

  15. Study identified novel mutations in CFH, CFHR5, CFI, CFB and C3 in American patients with atypical hemolytic uremic syndrome.

  16. Maps to between FHR-2 and the non-complement protein factor XIIIb at 1q32.

  17. FHR-5 shares properties of binding heparin and C-reactive protein and lipoprotein association with one or more of the other FHRs, but is unique among this family of proteins in possessing independent complement-regulatory activity.

  18. Identification of specific variants of variants of CFHR5 in membranoproliferative glomerulonephritis type II.

  19. CFHR5 genetic alterations may play a secondary role in the pathogenesis of haemolytic uraemic syndrome.

  20. No definitive pathogenic CFHR5 mutations have been found in any of 639 unrelated patients with age-related macular degeneration (AMD), indicating that sequence variations in CFHR5 do not play a major role in determining AMD susceptibility.

Complement Factor H-Related 5 (CFHR5) profil antigène

Profil protéine

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Gene names and symbols associated with CFHR5

  • complement factor H related 5 (CFHR5) anticorps
  • CFHL5 anticorps
  • CFHR5D anticorps
  • FHR-5 anticorps
  • FHR5 anticorps

Protein level used designations for CFHR5

complement factor H-related protein 5 , factor H-related protein 5

GENE ID SPECIES
81494 Homo sapiens
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