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binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function [RGD, Feb 2006].. De plus, nous expédions et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal DLGAP3 Primary Antibody pour IHC, ELISA - ABIN1003105
Takeuchi, Hata, Hirao, Toyoda, Irie, Takai: SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. dans The Journal of biological chemistry 1997
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Human Polyclonal DLGAP3 Primary Antibody pour IHC (p), WB - ABIN541332
Kindler, Rehbein, Classen, Richter, Böckers: Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA. dans Brain research. Molecular brain research 2004
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several rare variants of the DLGAP3 gene were found in this study which may be associated with schizophrenia.
This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment.
This study generated preliminary evidence to link SAPAP3 variants to the development of earlier onset obsessive-compulsive disorder.
DLGAP3 remains a promising candidate gene for Tourette Syndrome.
Sapap3 is a promising functional candidate gene for human grooming disorder (obsessive compulsive disorder).
Multiple rare SAPAP3 missense variants in trichotillomania and OCD.
Recorded ultrasonic vocalizations (USVs) from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period. Sapap3 mice display an increase in the number and duration of USV calls relative to sapap3 littermates, despite otherwise similar developmental profiles.
Both constitutive and induced genetic deletion of the melanocortin 4 receptor gene(MC4R) normalizes compulsive grooming and striatal electrophysiologic impairments in SAPAP3-null mice
The results of this study provide the first evidence for the mechanism by which the SAPAP family of scaffold proteins regulates AMPAR synaptic activity.
These results identify a role for SAPAP3 in the regulation of postsynaptic metabotropic glutamate receptors and endocannabinoid-mediated synaptic plasticity.
Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP.
binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function
, PSD-95/SAP90-binding protein 3
, SAP90/PSD 95 associated protein 3
, SAP90/PSD-95-associated protein 3
, disks large-associated protein 3
, prion protein ligand 8
, PSD-95/SAP90-associated protein-3
, discs, large (Drosophila) homolog-associated protein 3
, discs, large homolog-associated protein 3