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binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function [RGD, Feb 2006].. De plus, nous expédions et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal DLGAP3 Primary Antibody pour IHC, ELISA - ABIN1003105
Takeuchi, Hata, Hirao, Toyoda, Irie, Takai: SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. dans The Journal of biological chemistry 1997
Show all 4 Pubmed References
several rare variants of the DLGAP3 gene were found in this study which may be associated with schizophrenia.
This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 (Montrer SLC1A1 Anticorps) might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP (Montrer APEH Anticorps) treatment.
This study generated preliminary evidence to link SAPAP3 variants to the development of earlier onset obsessive-compulsive disorder.
DLGAP3 remains a promising candidate gene for Tourette Syndrome.
Sapap3 is a promising functional candidate gene for human grooming disorder (obsessive compulsive disorder).
Multiple rare SAPAP3 missense variants in trichotillomania and OCD.
Recorded ultrasonic vocalizations (USVs) from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period. Sapap3 mice display an increase in the number and duration of USV calls relative to sapap3 littermates, despite otherwise similar developmental profiles.
Both constitutive and induced genetic deletion of the melanocortin 4 receptor (Montrer MC4R Anticorps) gene(MC4R (Montrer MC4R Anticorps)) normalizes compulsive grooming and striatal electrophysiologic impairments in SAPAP3-null mice
These results identify a role for SAPAP3 in the regulation of postsynaptic metabotropic glutamate (Montrer GRIN1 Anticorps) receptors and endocannabinoid-mediated synaptic plasticity.
Semi-quantitative analysis of RNA levels in FMRP (Montrer FMR1 Anticorps) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (Montrer PSD Anticorps) components, such as Shank1 (Montrer SHANK1 Anticorps), SAPAP1 (Montrer DLGAP1 Anticorps)-3, PSD-95 (Montrer DLG4 Anticorps), and the glutamate (Montrer GRIN1 Anticorps) receptor subunits NR1 (Montrer GRIN1 Anticorps) and NR2B (Montrer GRIN2B Anticorps), are associated with FMRP (Montrer FMR1 Anticorps).
binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function
, PSD-95/SAP90-binding protein 3
, SAP90/PSD 95 associated protein 3
, SAP90/PSD-95-associated protein 3
, disks large-associated protein 3
, prion protein ligand 8
, PSD-95/SAP90-associated protein-3
, discs, large (Drosophila) homolog-associated protein 3
, discs, large homolog-associated protein 3