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The protein encoded by FGB is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. De plus, nous expédions Fibrinogen beta Chain Kits (56) et Fibrinogen beta Chain Protéines (21) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal FGB Primary Antibody pour ELISA, WB - ABIN969136
Vu, Bolton-Maggs, Parr, Morris, de Moerloose, Neerman-Arbez: Congenital afibrinogenemia: identification and expression of a missense mutation in FGB impairing fibrinogen secretion. dans Blood 2003
Show all 2 Pubmed References
All the exons and exon-intron boundaries of fibrinogen genes (FGA (Montrer FGA Anticorps), FGB and FGG (Montrer FGG Anticorps)) were analysed by direct DNA sequencing
High fibrinogen expression is associated with esophageal carcinoma.
Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 (Montrer IL6 Anticorps) and CRP (Montrer CRP Anticorps) were significantly higher in the patients with the CC and CT genotypes.
Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described.
Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.
FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion.
Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.
FGB mutations leading to congenital hypofibrinogenaemia
Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors.
There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1 (Montrer IGFBPI Anticorps), CCL20 (Montrer CCL20 Anticorps), CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase (Montrer TXK Anticorps) inhibitors
Data suggest that the interaction between Abeta and fibrinogen may be an important contributor to the vascular abnormalities found in Alzheimer's disease.
beta(3) integrin, thrombin (Montrer F2 Anticorps), and Ca(2 (Montrer CA2 Anticorps)+) play critical roles in platelet aggregation without fibrinogen or VWF (Montrer VWF Anticorps)
Data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock.
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
fibrinogen, B beta polypeptide
, fibrinogen beta chain
, B fibrinopeptide
, fibrinogen, beta chain
, B beta polypeptide
, fibrinogen, beta polypeptide
, liver regeneration-related protein LRRG036/LRRG043/LRRG189
, fibrinogen beta chain-like
, fibrinogen B-beta subunit