Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Kits ELISA

The protein encoded by GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. De plus, nous expédions GNE Anticorps (62) et GNE Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
GNE 10020 Q9Y223
GNE 50798 Q91WG8
GNE 114711 O35826
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Plus Kits ELISA pour GNE partenaires d'interaction

Zebrafish Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. The results demonstrate a critical novel role for gne in embryonic development and particularly in myofiber development, muscle integrity and activity.

Human Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. the interaction between GNE and alpha-actinin 1 (Montrer ACTN1 Kits ELISA) and alpha-actinin 2 (Montrer ACTN2 Kits ELISA) occur at different sites in the alpha-actinin (Montrer ACTN1 Kits ELISA) molecules and that for alpha-actinin 2 (Montrer ACTN2 Kits ELISA) the interaction site is located at the C-terminus of the protein.

  2. the half-life of the M743T variant is two times longer than for the wild-type GNE protein. This study provides that the balance of phosphorylation and O-GlcNAcylation is decisive involved in efficiency and regulation of GNE.

  3. The results of this study widen the spectra of mutations to copy number variations encompassing 5'UTR (Montrer UTS2R Kits ELISA), underscoring the pivotal role of the hGNE1 transcript in GNE myopathy.

  4. the complex crystal structure of the N-terminal epimerase part of human GNE shows a tetramer in which UDP binds to the active site and CMP (Montrer MATN1 Kits ELISA)-Neu5Ac binds to the dimer-dimer interface.

  5. This study confirms that c.2228T>C (p.M743T) is the most prevalent disease-causing variant in the non-Jewish Persian population, but other GNE variants can cause GNE myopathy in this population.

  6. examined the consequences of the mutated GNEM743T enzyme in myoblasts cultures, depicted by the pattern of central signaling proteins of the PI3K (Montrer PIK3CA Kits ELISA)/AKT (Montrer AKT1 Kits ELISA), BCL2 (Montrer BCL2 Kits ELISA) and ARTS/XIAP (Montrer XIAP Kits ELISA) pathways

  7. Novel GNE mutations were linked to GNE myopathy in patients from mainland China.

  8. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  9. mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells

  10. GNE myopathy is an autosomal recessive muscle disease caused by biallelic mutations in GNE, a gene encoding for a single protein with key enzymatic activities--{REVIEW}

Mouse (Murine) Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  2. Analysis of differential Gne transcript expression of the two splice variants, Gne1 and Gne2.

  3. GNE is strongly involved in cardiac tissue and skeletal muscle early survival and organization.

  4. Our findings suggest that GNE expression is induced when myofibers are damaged or regenerating, and that GNE plays a role in muscle regeneration.

  5. sialic acid biosynthesis is involved in proliferation and expression of GNE

  6. inactivation of the UDP-GlcNAc (Montrer B3GNT2 Kits ELISA) 2-epimerase (Montrer RENBP Kits ELISA) by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development

  7. compared the amount of membrane-bound sialic acids of wildtype mice with those of heterozygous GNE-deficient mice

  8. Mutations in the Gne enzyme, which encode the rate-limiting enzyme in sialic acid biosynthesis, are causative of distal myopathies with rimmed vacuoles or hereditary inclusion body myopathy.

GNE profil antigène

Antigen Summary

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Gene names and symbols associated with GNE

  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) anticorps
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (gne) anticorps
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Gne) anticorps
  • 2310066H07Rik anticorps
  • DMRV anticorps
  • GLCNE anticorps
  • GNE anticorps
  • IBM2 anticorps
  • MGC145505 anticorps
  • NM anticorps
  • Uae1 anticorps
  • zgc:77657 anticorps

Protein level used designations for GNE

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase-like , N-acylmannosamine kinase , UDP-GlcNAc-2-epimerase/ManAc kinase , UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , UDP-N-acetylglucosamine-2-epimerase/N- acetylmannosamine kinase

GENE ID SPECIES
641344 Sus scrofa
393857 Danio rerio
427285 Gallus gallus
465094 Pan troglodytes
481607 Canis lupus familiaris
693525 Macaca mulatta
780185 Xenopus (Silurana) tropicalis
782201 Bos taurus
100171416 Pongo abelii
100340455 Oryctolagus cuniculus
100414213 Callithrix jacchus
100481169 Ailuropoda melanoleuca
100541275 Meleagris gallopavo
100554566 Anolis carolinensis
100589824 Nomascus leucogenys
10020 Homo sapiens
50798 Mus musculus
114711 Rattus norvegicus
100689450 Cricetulus griseus
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