anti-Interferon Inducible GTPase 1 (IIGP1) Anticorps

GTPase with low activity. De plus, nous expédions et beaucoup plus de produits pour cette protéine.

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IIGP1 60440 Q9QZ85
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Souris Lapin Inconjugué WB 100 μg 11 to 14 Days
Souris Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using Iigp1 antibody (ABIN6294082) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60S. 50 μL 11 to 13 Days

Plus d’anticorps contre Interferon Inducible GTPase 1 partenaires d’interaction

Mouse (Murine) Interferon Inducible GTPase 1 (IIGP1) interaction partners

  1. The study determined the crystal structure of an oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable GTP analog.

  2. These data identify Toxoplasma gondii GRA7 as a regulator for ROP18-specific inactivation of murine Irga6.

  3. ROP5 uses a highly polymorphic surface to bind adjacent to the nucleotide-binding domain of an IRG and that this produces a profound allosteric change in the IRGa6 structure. [Rop5]

  4. This study defines the catalytic G-domain interface by mutagenesis and presents a model of how GTP hydrolysis is activated in Irga6 complexes, based on the substrate-twinning reaction mechanism of the signal recognition particle and its receptor (SRalpha).

  5. Toxoplasma gondii ROP5 binding alters the conformation of the Irga6 active site.

  6. results implicate Irga6 in the control of infection with T. gondii and further highlight the importance of the IRG system for resistance to this pathogen

  7. Virulent T. gondii strain ROP18 kinase phosphorylates host Irga6 at two threonines in the nucleotide-binding domain, biochemically inactivating the GTPase and inhibiting its accumulation and action at the T. gondii parasitophorous vacuole membrane.

  8. role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system

  9. study clearly adds interferon inducible GTPase(IIGP1) to the small group of cooperative GTPase families that appear to characterize the development of intracellular resistance during the interferon response to infection

  10. Identified a microtubule binding protein hook3 as its interacting protein.

  11. IIGP1 is associated with the endoplasmic reticulum by an N-terminal myristoylation modification

  12. Here we present the first crystal structure of a member of the p47 GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. Sequence comparison and secondary structure prediction suggest it is a valid model for the p47 GTPase family

  13. Differential induction by various gram-negative lipopolysaccharides was myeloid differentiation factor 88 (MyD88)-independent

Interferon Inducible GTPase 1 (IIGP1) profil antigène

Profil protéine

GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.

Gene names and symbols associated with IIGP1

  • interferon inducible GTPase 1 (Iigp1) anticorps
  • 2900074L10Rik anticorps
  • AI046432 anticorps
  • AW111922 anticorps
  • Ifgga1 anticorps
  • Iigp anticorps
  • Irga6 anticorps

Protein level used designations for IIGP1

interferon-gamma-inducible GTPase Ifgga1 protein , interferon-inducible GTPase 1

60440 Mus musculus
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