Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Kits ELISA

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. De plus, nous expédions IDH2 Anticorps (119) et IDH2 Protéines (20) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Humain 0.074 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
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Plus Kits ELISA pour IDH2 partenaires d'interaction

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Four clinical cases that identify mutant IDH isoform switching, either from mutant isocitrate dehydrogenase 1 (IDH1) to mutant IDH2 or vice versa, as a mechanism of acquired clinical resistance to IDH inhibition in solid and liquid tumors.

  2. The present study showed for the first time, to the best of our knowledge, that IDH2 plays a compensatory role in maintaining reductive carboxylationdependent lipogenesis and proliferation in IDH1 R132H tumor cells. Therefore, IDH2 could serve as a potential antitumor target for IDH1mutant tumors, which may provide a new strategy for treatment.

  3. Enasidenib-induced eosinophilic differentiation in a patient with acute myeloid leukaemia with IDH2 and U2AF1 mutations.

  4. More than 95% acute myeloid leukemia patients with IDH1/2 mutation commonly show additional mutations

  5. This review focuses on the role of IDH1 and IDH2 mutations in diffuse gliomas

  6. IDH2 mutation is associated with glioma.

  7. This study identified a seven-gene signature that can provide a more accurate predictor of 3 years and 5 years for patients with IDH-mutant glioma.

  8. IDH1/2(MUT) inhibitors protected against these treatments.

  9. Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.

  10. IDH2 promotes the Warburg effect and lung cancer cell growth, which is mediated through HIF1alpha activation followed by decreased alpha-KG.

  11. IDH2 gene mutations associate with prognosis of acute myeloid leukemia patients, R140Q mutations have no effect on prognosis of patients

  12. IDH2 mutation is associated with minimal residual disease assessment in acute myeloid leukemia.

  13. Alterations of EZH2, KMT2C, and CHD4 at genetic level or protein level could perturb epigenetic program, leading to malignant transformation in glioma.

  14. eason that there is a mutation in the tumor cells is associated with de novo blocking differentiation processes and development of brain cells in the development process, as evidenced by severe cerebral hypoplasia in patients with congenital forms of this mutation of IDH2

  15. Variants were identified using the Ion Torrent Variant Caller Plugin and reference genome hg19. Golden Helix's SVS software was used for variant annotation and prediction of significance. Nine samples (1.1%) from 8 patients harbored an IDH1 (3 p.R132C and 2 p.R132L) or IDH2 mutation

  16. IDH2 levels in the serum could be a new effective biomarker for the diagnosis and prognosis of non-small-cell lung cancer.

  17. The present review discusses the molecular basis of the sensitivity of IDH1/2-mutated cancers with respect to the function of mutated IDH1/2 in cellular processes and their interactions with novel IDH1/2-mutant inhibitors. Finally, lessons learned from IDH1/2 mutations for future clinical applications in IDH1/2 wild-type cancers are discussed. [review]

  18. Mutations in the IDH2 gene were found in 7.5% of cases, with a predominance of the nonsynonymous R172K and R172W mutations

  19. IDH1 or IDH2 mutations play a limited role in the development of ESCC. 2HG is potentially synthesized to high levels in the absence of IDH1 and IDH2 mutations, and this may correlate with progression of ESCCs.

  20. x-ray crystallography of mutant IDH2 binding of an inhibitor (AG-881) to an allosteric site, and compared to IDH1 allosteric site binding

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. This was accompanied by decreased NADPH redox state and decreased activity of TXNRD2 in the mitochondria of the HEI-OC1 cells. Therefore, IDH2 functions as the principal source of NADPH for the mitochondrial thioredoxin antioxidant defense and plays an essential role in protecting hair cells and neurons against oxidative stress in the cochlea of male mice.

  2. The IDH2 deficiency induced endothelial inflammation via p66shc-mediated mitochondrial oxidative stress.

  3. IDH2 deficiency downregulated pro-inflammatory mediators via modulation of the ERK and NF-kappaB pathways

  4. IDH2 knock out mice exhibit a decreased susceptibility to lipopolysaccharide (LPS)-induced lung injury. Depletion of IDH2 attenuates LPS-induced inflammatory response.

  5. role in maintaining the spinal structure by affecting the homeostatic balance between osteoclasts and osteoblasts

  6. our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS and suggest unique therapeutic strategies for the prevention of skin pigmentation.

  7. Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.

  8. present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung

  9. IDH2 deficiency leads to increased mitochondrial ROS levels, activation of NF-kappaB and apoptosis of IEC in DSS-induced colitis.

  10. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  11. The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFkappaB signaling pathways.

  12. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  13. Increased obesity resistance and insulin sensitivity in mice lacking the IDH2 gene has been documented.

  14. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD expression, eNOS phosphorylation and NO production in endothelial cells

  15. Idh2R140Q mice displayed significantly elevated 2HG levels.

  16. These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging.

  17. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  18. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  19. IDH2 and NPM1 mutations synergize in the development and maintenance of acute myeloid leukemia stem-like cells.

  20. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx activity.

IDH2 profil antigène

Antigen Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2) anticorps
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) anticorps
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) anticorps
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2) anticorps
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S) anticorps
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) anticorps
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867) anticorps
  • D2HGA2 anticorps
  • E430004F23 anticorps
  • F6P23.14 anticorps
  • F6P23_14 anticorps
  • ICD-M anticorps
  • IDH anticorps
  • Idh-2 anticorps
  • IDH-II anticorps
  • IDH2 anticorps
  • IDHM anticorps
  • IDP anticorps
  • IDPm anticorps
  • isocitrate dehydrogenase II anticorps
  • isocitrate dehydrogenase subunit 2 anticorps
  • mNADP-IDH anticorps
  • wu:fb33c06 anticorps
  • wu:fk31e05 anticorps
  • wu:fq43b01 anticorps
  • zgc:55485 anticorps

Protein level used designations for IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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