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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. De plus, nous expédions MAP3K9 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MAP3K9 Primary Antibody pour IHC (p), WB - ABIN392422
Strath, Georgopoulos, Kellam, Blair: Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation. dans BMC genomics 2009
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Human Polyclonal MAP3K9 Primary Antibody pour IHC (p), ELISA - ABIN543253
Gallo, Mark, Scadden, Wang, Gu, Godowski: Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. dans The Journal of biological chemistry 1994
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Data report that MKL1 was both sufficient and necessary for p65-dependent pro-inflammatory transcriptional program. MKL1 deficiency erased key histone modifications synonymous with transactivation on p65 target promoters. Specifically, MKL1 defined histone H3K4 trimethylation landscape for NF-kappaB dependent transcription.
There was a negatively relationship between miR-15a and MAP3K9 expression in NP cells.
miR148b directly targeted mitogenactivated protein kinase (MAPK) kinase kinase 9 (MAP3K9), an upstream activator of MAPK kinase/cJun Nterminal kinase (JNK) signaling, suppressing the protein but not the mRNA levels.
identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation
It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9.
estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
mixed lineage kinase 1 (tyr and ser/thr specificity)
, mitogen activated protein kinase kinase kinase 9
, mixed-lineage kinase 1