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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. De plus, nous expédions MAP3K9 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MAP3K9 Primary Antibody pour IHC (p), WB - ABIN392422
Strath, Georgopoulos, Kellam, Blair: Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation. dans BMC genomics 2009
Show all 3 Pubmed References
Data report that MKL1 (Montrer MKL1 Anticorps) was both sufficient and necessary for p65 (Montrer GORASP1 Anticorps)-dependent pro-inflammatory transcriptional program. MKL1 (Montrer MKL1 Anticorps) deficiency erased key histone modifications synonymous with transactivation on p65 (Montrer GORASP1 Anticorps) target promoters. Specifically, MKL1 (Montrer MKL1 Anticorps) defined histone H3K4 trimethylation landscape for NF-kappaB (Montrer NFKB1 Anticorps) dependent transcription.
There was a negatively relationship between miR (Montrer MLXIP Anticorps)-15a and MAP3K9 expression in NP cells.
miR148b directly targeted mitogenactivated protein kinase (Montrer CDK7 Anticorps) (MAPK (Montrer MAPK1 Anticorps)) kinase kinase 9 (MAP3K9), an upstream activator of MAPK (Montrer MAPK1 Anticorps) kinase/cJun (Montrer JUN Anticorps) Nterminal kinase (JNK (Montrer MAPK8 Anticorps)) signaling, suppressing the protein but not the mRNA levels.
identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4 (Montrer FGFR4 Anticorps), MAP3K9, and PAK5 (Montrer PAK6 Anticorps). Mutations in these kinases are activating toward the ERK (Montrer EPHB2 Anticorps) pathway, and targeted depletion of the mutated kinases inhibits proliferation
It was found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 (Montrer MAP3K5 Anticorps) or MAP3K9.
estrogen receptor-alpha (Montrer ESR1 Anticorps) transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
There is extensive functional redundancy between MLK1 and MLK2 (Montrer MAP3K10 Anticorps), and the other member of the family, MLK3 (Montrer KCNK7 Anticorps), none of which are required for survival in mouse.
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
mixed lineage kinase 1 (tyr and ser/thr specificity)
, mitogen activated protein kinase kinase kinase 9
, mixed-lineage kinase 1