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MMRN2 encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. De plus, nous expédions Multimerin 2 Anticorps (30) et Multimerin 2 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Results provide evidence identifying MMRN2 as a key molecule in regulating endothelial cell (EC) function and demonstrate that, during the angiogenic stimulation, its expression is controlled both transcriptionally and post-translationally by MMP9 (Montrer MMP9 Kits ELISA) for efficient EC sprouting.
Data identify MMRN2 as a specific ligand for CD93 (Montrer CD93 Kits ELISA). CD93 (Montrer CD93 Kits ELISA) and MMRN2 are co-expressed in the blood vessels of various tumors. Moreover, disruption of the CD93 (Montrer CD93 Kits ELISA)-MMRN2 interaction reduced endothelial cell adhesion and migration. Site-directed mutagenesis identified different residue hotspots either directly or indirectly involved in the binding and propose a molecular model in which the coiled-coil domain of MMRN2 is engaged.
These findings identify novel protein interactions involving CLEC14A (Montrer CLEC14A Kits ELISA), CD93 (Montrer CD93 Kits ELISA) and CD248 (Montrer CD248 Kits ELISA) with MMRN2 as targetable components of vessel formation
Results suggest that CLEC14A (Montrer CLEC14A Kits ELISA)-MMRN2 binding has a role in inducing sprouting angiogenesis during tumor growth, which has the potential to be manipulated in future antiangiogenic therapy design.
CLEC14A (Montrer CLEC14A Kits ELISA) is a matrix component which binds to MMRN2 in the process of endothelial cells transformation in tumor angiogenesis.
MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth
Mmrn2 interacts with anthrax protective antigen.
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6.
, elastin microfibril interfacer 3
, EMILIN-like protein EndoGlyx-1
, elastin microfibril interface located protein 3
, endoGlyx-1 p125/p140 subunit