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MMRN2 encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. De plus, nous expédions Multimerin 2 Anticorps (30) et Multimerin 2 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Results provide evidence identifying MMRN2 as a key molecule in regulating endothelial cell (EC) function and demonstrate that, during the angiogenic stimulation, its expression is controlled both transcriptionally and post-translationally by MMP9 for efficient EC sprouting.
Data identify MMRN2 as a specific ligand for CD93. CD93 and MMRN2 are co-expressed in the blood vessels of various tumors. Moreover, disruption of the CD93-MMRN2 interaction reduced endothelial cell adhesion and migration. Site-directed mutagenesis identified different residue hotspots either directly or indirectly involved in the binding and propose a molecular model in which the coiled-coil domain of MMRN2 is engaged.
These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation
Results suggest that CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumor growth, which has the potential to be manipulated in future antiangiogenic therapy design.
CLEC14A is a matrix component which binds to MMRN2 in the process of endothelial cells transformation in tumor angiogenesis.
MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth
Mmrn2 interacts with anthrax protective antigen.
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6.
, elastin microfibril interfacer 3
, EMILIN-like protein EndoGlyx-1
, elastin microfibril interface located protein 3
, endoGlyx-1 p125/p140 subunit