Mutated in Colorectal Cancers Protéines (MCC)

MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. De plus, nous expédions MCC Anticorps (67) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MCC 4163 P23508
Souris MCC MCC 328949  
Rat MCC MCC 307449  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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MCC Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,

Plus protéines pour Mutated in Colorectal Cancers (MCC) partenaires d'interaction

Zebrafish Mutated in Colorectal Cancers (MCC) interaction partners

  1. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt (Montrer WNT2 Protéines) signaling during convergence and extension in zebrafish.

Human Mutated in Colorectal Cancers (MCC) interaction partners

  1. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (Montrer RPS6KA2 Protéines) and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (Montrer RPS6KA2 Protéines) = ribosomal protein S6 kinase 2 (Montrer RPS6KA3 Protéines); MCC = mutated in colorectal cancer protein)

  2. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression.

  3. Significantly, miR (Montrer MLXIP Protéines)-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4 (Montrer SMAD4 Protéines).

  4. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (Montrer RAB1A Protéines) in B cells

  5. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (Montrer SIRT1 Protéines)

  6. targeted by miR (Montrer MLXIP Protéines)-494, which is overexpressed in hepatocellular carcinoma

  7. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.

  8. we have shown that promoter methylation of the APC (Montrer APC Protéines) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.

  9. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.

  10. MCC is a nuclear, beta-catenin-interacting protein (Montrer CTNNBIP1 Protéines) that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signal transduction.

Mouse (Murine) Mutated in Colorectal Cancers (MCC) interaction partners

  1. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (Montrer RAB1A Protéines) in B cells

Profil protéine MCC

Profil protéine

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MCC

  • mutated in colorectal cancers (MCC)
  • mutated in colorectal cancers (mcc)
  • mutated in colorectal cancers (Mcc)
  • D18Ertd451e Protéine
  • E330037C19 Protéine
  • MCC Protéine
  • MCC1 Protéine
  • RGD1561988 Protéine

Protein level used designations for MCC

mutated in colorectal cancers , colorectal mutant cancer protein

GENE ID SPECIES
100064404 Equus caballus
415603 Gallus gallus
462002 Pan troglodytes
694270 Macaca mulatta
100015680 Monodelphis domestica
100216150 Xenopus (Silurana) tropicalis
100354734 Oryctolagus cuniculus
100473268 Ailuropoda melanoleuca
100537329 Danio rerio
4163 Homo sapiens
328949 Mus musculus
307449 Rattus norvegicus
611208 Canis lupus familiaris
616704 Bos taurus
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