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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. De plus, nous expédions MCC Anticorps (68) et beaucoup plus de produits pour cette protéine.
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The PDZ domain protein Mcc is a novel effector of non-canonical Wnt (Montrer WNT2 Protéines) signaling during convergence and extension in zebrafish.
Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin (Montrer CDH1 Protéines) mediated cell-cell adhesion in colorectal cancer cells.
Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble (Montrer SCRIB Protéines) PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (Montrer RPS6KA2 Protéines) and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (Montrer RPS6KA2 Protéines) = ribosomal protein S6 kinase 2 (Montrer RPS6KA3 Protéines); MCC = mutated in colorectal cancer protein)
MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression.
Significantly, miR (Montrer MLXIP Protéines)-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4 (Montrer SMAD4 Protéines).
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (Montrer RAB1A Protéines) in B cells
cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (Montrer SIRT1 Protéines)
targeted by miR (Montrer MLXIP Protéines)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.
we have shown that promoter methylation of the APC (Montrer APC Protéines) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein