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NOX3 encodes a member of the NOX family of NADPH oxidases.
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Mouse (Murine) Polyclonal NOX3 Primary Antibody pour IHC - ABIN966689
Chéret, Gervais, Lelli, Colin, Amar, Ravassard, Mallet, Cumano, Krause, Mallat: Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
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Human Polyclonal NOX3 Primary Antibody pour IHC - ABIN966688
Cheng, Cao, Xu, van Meir, Lambeth: Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. dans Gene 2001
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Human Polyclonal NOX3 Primary Antibody pour IHC, ELISA - ABIN1535076
Du, Yang, Hu, Sun, Zhang, Peng, Zhong, Huang, Kong: A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. dans Hearing research 2012
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Human Polyclonal NOX3 Primary Antibody pour IF (p), IHC (p) - ABIN702595
Wakatsuki, Furuno, Ohshima, Araki: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. dans The Journal of cell biology 2015
Hsp70 (Montrer HSP70 Anticorps) activates Stat3 (Montrer STAT3 Anticorps) and suppresses Nox3 via TLR4 (Montrer TLR4 Anticorps)
Together, these findings reveal that Nox2 (Montrer CYBB Anticorps) is a Zn(2+)-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy. Understanding the specific mechanisms by which ZnD contributes to kidney damage may have an important impact on the treatment of chronic kidney disease.
Nox3 mutants and heterozygotes demonstrated a greater susceptibility to noise-induced hearing loss.
Although Nox3 overexpression revealed no apparent effect, depletion of Nox3 decreased the number of spermatogonial stem cells in both cultured spermatogonia and freshly isolated testis cells.
Mutations of Nox3 include retrovirus insertion, missense mutations, splice donor mutation, a splice acceptor mutation and premature translational termination.
palmitate-induced ROS (Montrer ROS1 Anticorps) generation and that NOX3-derived ROS (Montrer ROS1 Anticorps) may drive palmitate-induced hepatic insulin (Montrer INS Anticorps) resistance through JNK (Montrer MAPK8 Anticorps) and p38(MAPK (Montrer MAPK14 Anticorps)) pathways.
an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3), identifies Nox3 as a protein with a clear enzymatic function indispensable for otoconia morphogenesis
NOX3 is a relevant source of ROS (Montrer ROS1 Anticorps) generation in the cochlear and vestibular systems and that NOX3-dependent ROS (Montrer ROS1 Anticorps) generation might contribute to hearing loss and balance problems in response to ototoxic drugs.
genetic variants in NOX3 may confer susceptibility to antithyroid drug-induced apoptosis of granulocytes.
In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 (Montrer NFE2L2 Anticorps) that increases the risk of PGD (Montrer PGD Anticorps).
Reduced matrigel invasion was mediated by reduced ROS (Montrer ROS1 Anticorps) levels coinciding with decreased expression of NADPH oxidase 2 (Montrer CYBB Anticorps), 3, 4 and 5 involved in ROS (Montrer ROS1 Anticorps) production.
Down-regulation of NOX3 using siRNA prevented TNF-alpha (Montrer TNF Anticorps)-induced decrease of cellular glycogen (Montrer GYS1 Anticorps).
Nox3 is regulated by NOXO1 (Montrer NOXO1 Anticorps), p47phox, and p67phox (Montrer NCF2 Anticorps)
Nox3 functions together with p22(phox (Montrer CYBA Anticorps)) as an enzyme constitutively producing superoxide
Rac1 regulates both oxidases Nox1 (Montrer NOX1 Anticorps) and Nox3 through the Nox activators
In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase (Montrer NOX1 Anticorps), plays an integral role in insulin (Montrer INS Anticorps)-induced p42 (Montrer EPB42 Anticorps)/44 Mitogen-activated protein kinase (Montrer MAPK1 Anticorps) signal transmission and VEGF-A (Montrer VEGFA Anticorps) production.
Roles for p22phox (Montrer CYBA Anticorps) at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane.
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
, NADPH oxidase catalytic subunit-like 3
, gp91phox homolog 3
, mitogenic oxidase 2
, NADPH oxidase 3
, predicted NADPH oxidase-3
, NADPH oxidase 3-like