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Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. De plus, nous expédions OTUD7B Protéines (7) et et beaucoup plus de produits pour cette protéine.
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Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma and contribute to the selection of patients who may benefit from adjuvant transcatheter arterial chemoembolization to prevent recurrence.
TRAF2 (Montrer TRAF2 Anticorps) and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 (Montrer CRTC2 Anticorps) signalling
Findings indicated both cezanne-1 and IGF1R (Montrer IGF1R Anticorps) expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R (Montrer IGF1R Anticorps) expression.
expression of OTUD7B and NIK (Montrer MAP3K14 Anticorps) were negatively correlated in non-small cell lung cancer tumor samples. The higher expression of OTUD7B was associated with smaller tumor size, less lymph node metastasis and earlier TNM (Montrer ODZ1 Anticorps) stage. the high expression of OTUD7B was associated with good prognosis of NSCLC patients, and a high OTUD7B/low NIK (Montrer MAP3K14 Anticorps) index can predict even better prognosis. also, OTUD7B is an independent markers of survival.
crystal structures of Cezanne alone and in complex with monoubiquitin and Lys11-linked diubiquitin (Montrer UBD Anticorps), in combination with hydrogen-deuterium exchange mass spectrometry, enable a reconstruction of the enzymatic cycle in great detail
these data reveal a novel mechanism for the regulation of the expression of HIF2a (Montrer EPAS1 Anticorps), demonstrating that the HIF2a (Montrer EPAS1 Anticorps) promoter is regulated by E2F1 (Montrer E2F1 Anticorps) directly and that Cezanne regulates HIF2a (Montrer EPAS1 Anticorps) expression through control of E2F1 (Montrer E2F1 Anticorps) levels
Taken together, these results suggest that hepatitis C virus NS5A protein interacts with OTUD7B, thereby modulating its deubiquitinase activity.
Cezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in hepatocellular carcinoma patients.
data suggest that Cezanne is essential for HIF-1alpha (Montrer HIF1A Anticorps) protein stability and that loss of Cezanne stimulates HIF-1alpha (Montrer HIF1A Anticorps) degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy.
Genome wide association study shows evidence of association between mammographic density and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 (Montrer MTMR11 Anticorps) and rs67807996 in gene OTUD7B.
Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma.
These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 (Montrer ZAP70 Anticorps) function.
Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-kappaB (Montrer NFKB1 Anticorps) activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3 (Montrer TRAF3 Anticorps)
DJ-1 (Montrer PARK7 Anticorps) enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB (Montrer NFKB1 Anticorps).
Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B.
OTU domain containing 7B
, zinc finger protein Cezanne
, OTU domain-containing protein 7B
, zinc finger, A20 domain containing 1
, cellular zinc finger anti-NF-kappa-B protein
, cellular zinc finger anti-NF-kappaB Cezanne
, zinc finger A20 domain-containing protein 1
, TRAF binding domain containing 2