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Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.
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No germline mutations were found in the OLA1 gene in in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer.
OLA1 contributes to epithelial-mesenchymal transition by modulating the GSK3beta/Snail (Montrer SNAI1 Kits ELISA)/E-cadherin (Montrer CDH1 Kits ELISA) signaling, and its overexpression is associated with clinical progression and poor survival in lung cancer patients.
Our work suggests that OLA1 is a novel translational GTPase (Montrer RACGAP1 Kits ELISA) and plays a suppressive role in translation and cell survival, as well as cancer growth and progression.
OLA1 plays an important negative role in cell adhesion and spreading, in part through the regulation of FAK (Montrer PTK2 Kits ELISA) expression and cofilin (Montrer CFL1 Kits ELISA) phosphorylation, and manipulation of OLA1 may lead to significant changes in cell adhesion and the associated phenotypes.
OLA1 plays an important role in centrosome regulation together with BRCA1.
Downregulation of OLA1 in mammalian cells by either RNAi or targeted gene disruption results in reduced steady-state levels of HSP70 (Montrer HSP70 Kits ELISA), impaired HSP70 (Montrer HSP70 Kits ELISA) induction by heat, and functionally, increased cellular sensitivity to heat shock.
DOC45 is a novel ATPase (Montrer DNAH8 Kits ELISA) that is linked to cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker.
knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS (Montrer ROS1 Kits ELISA) levels
Results indicate that Gbp45/OLA1 plays important roles in cell proliferation and death related to mitochondrial function.
OLA1 suppresses the antioxidant response through nontranscriptional mechanisms.
cell transformation induced by the metal mixture NaAsO2, CdCl2, and Pb(C2H3O2)2.3H2O through ROS (Montrer ROS1 Kits ELISA) generation was rescued by OLA1 knockdown during the initiation stage of morphological transformation.
Data demonstrate that OLA1 is required for normal progression of mammalian development. OLA1 plays an important role in promoting cell proliferation at least in part through suppression of p21 and organogenesis via factors yet to be discovered.
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity).
obg-like ATPase 1
, Obg-like ATPase 1
, GTP-binding protein PTD004
, GTP-binding protein 9 (putative)
, DNA damage-regulated overexpressed in cancer 45 protein
, homologous yeast-44.2 protein