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C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]..
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a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and req (Montrer MLL4 Kits ELISA)uires PTIP for interac (Montrer HIST3H3 Kits ELISA)tion with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
PA1 expression was observed in both nucleus (mainly)and cytoplasm from breast cancer tissue samples. PA1 nuclear expression was correlated with postmenopausal, smaller tumor size, negative Ki67 (Montrer MKI67 Kits ELISA), positive AR and positive ERbeta (Montrer ESR2 Kits ELISA). PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS. For those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS.
PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene
PA1 (C16orf53) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4 (Montrer MLL2 Kits ELISA)-containing histone H3 (Montrer HIST3H3 Kits ELISA) K4 methyltransferase complex.
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007
PAXIP1-associated glutamate-rich protein 1
, PAXIP1-associated protein 1
, PTIP-associated protein 1
, PTIP-associated 1
, PTIP-associated 1 protein
, glutamate-rich coactivator associated with SRC1
, glutamate-rich coactivator interacting with SRC1/NCOA1