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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.
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Mammalian Monoclonal KCNA3 Primary Antibody pour ISt, IHC - ABIN1304749
Cidad, Novensà, Garabito, Batlle, Dantas, Heras, López-López, Pérez-García, Roqué: K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. dans Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014
Show all 21 Pubmed References
Kv1.3 methylation may serve as diagnostic and prognostic markers in colorectal cancer.
the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 (Montrer KCNE4 Anticorps) interaction.
results identify a caveolin-binding domain in Kv1 (Montrer KCNA5 Anticorps) channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes
we report that Kv1.3-NPs (Montrer NPS Anticorps) reduced NFAT (Montrer NFATC1 Anticorps) activation and CD40L (Montrer CD40LG Anticorps) expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs (Montrer NPS Anticorps) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.
The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.
Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF (Montrer SNRPE Anticorps) signaling.
Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr (Montrer TYR Anticorps)-447 by MAP kinase (Montrer MAPK1 Anticorps) signal cascade appears crucial.
concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (Montrer EPHB2 Anticorps).
The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.
Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR (Montrer FRAP1 Anticorps) signaling pathway.
Data show that cereblon (CRBN (Montrer CRBN Anticorps)) limits CD4 (Montrer CD4 Anticorps)(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Montrer KCNAB2 Anticorps) (Kv1.3) expression.
Following differentiation with LPS (Montrer TLR4 Anticorps) or a combination of LPS (Montrer TLR4 Anticorps) and IFN-gamma (Montrer IFNG Anticorps) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (Montrer CSN3 Anticorps) 3.1 and Kir (Montrer GEM Anticorps) currents, while microglia differentiated with IL-4 (Montrer IL4 Anticorps) exhibited large Kir (Montrer GEM Anticorps) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (Montrer CSN3 Anticorps) 3.1 currents were generally low
These studies reveal unexpected roles of Kv1.3 subunit-containing channels in the regulation of firing patterns of striatal cholinergic interneurons, which were thought to be largely dependent on KCa (Montrer CSN3 Anticorps) channels.
promotes B lymphocyte (Montrer AKAP17A Anticorps) activation, proliferation and monocyte chemotaxis
Changes in Kv1.3 subcellular distribution upon EGFR (Montrer EGFR Anticorps) activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.
Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction
A compensatory upregulation of the potassium channels K2P3.1 (Montrer KCNK3 Anticorps) and KV1.3 seems to counterbalance the deletion of K2P5.1 (Montrer KCNK5 Anticorps).
JAK2 (Montrer JAK2 Anticorps) participates in the signalling, regulating the voltage-gated K(+) channel (Montrer KCND3 Anticorps) KCNA3.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
glibenclamide-sensitive voltage-gated potassium channel
, potassium voltage-gated channel subfamily A member 3
, potassium voltage-gated channel, shaker-related subfamily, member 3
, shaker-like potassium channel subunit Kv1.3B
, potassium channel 3
, type n potassium channel
, voltage-gated K(+) channel HuKIII
, voltage-gated potassium channel protein Kv1.3
, voltage-gated potassium channel subunit Kv1.3
, Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
, potassium voltage gated channel, shaker related subfamily, member 3
, voltage-gated potassium channel subunit Kv3
, Shaker-like voltage-gated potassium channel cKv1.1
, shaker subfamily potassium channel Kv1.3 alpha subunit
, voltage-gated Kv1.3 potassium channel