anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Anticorps

PIM2 encodes a protooncogene that acts as a serine/threonine protein kinase. De plus, nous expédions Proto-Oncogene Pim-2 (Serine Threonine Kinase) Protéines (18) et Proto-Oncogene Pim-2 (Serine Threonine Kinase) Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PIM2 11040 Q9P1W9
PIM2 317366  
PIM2 18715 Q62070
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Top anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) Anticorps sur anticorps-enligne.fr

Showing 10 out of 130 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-PIM2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-PIM2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: PIM2 Antibody [NBP1-86193] - Lane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 17.5 | Lane 2: RT-4 | Lane 3: EFO-21 | Lane 4: A-431 | Lane 5: Liver | Lane 6: Tonsil Immunocytochemistry/Immunofluorescence: PIM2 Antibody [NBP1-86193] - Immunofluorescent staining of human cell line U-251MG shows positivity in nuclei & cytoplasm. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué IHC (p), IP, WB Western blot analysis of anti-PIM2 Antibody (C-term) (ABIN392442) in Hela cell line lysates (35 µg/lane). PIM2 (arrow) was detected using the purified polyclonal antibody. PIM proteins were immunoprecipitated from MV4.11 cells and the agarose-protein A-immunoprecipitate complex was tested for its ability to phosphorylate BAD in vitro in the presence or absence of K00135. Phosphorylation of BAD (both on Ser112 and Ser136, detected by WB with phospho-specific antibodies) was abrogated on addition of the compound. Asterisks, strong bands corresponding to the heavy chain of the anti-PIM2 rabbit antibody recognized by the antirabbit immunoglobulin G secondary antibody. Beads alone (without anti-PIM antibodies) were incubated with the MV4.11 extract and used for the same in vitro phosphorylation reaction as a negative control. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Souris Inconjugué IF, IHC, IHC (p), WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Souris Inconjugué FACS, IF, IHC, IHC (p), IP, WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Chèvre Inconjugué ELISA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tag probed with ABIN1590033 (0.1 µg/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with ABIN1590033 (0.1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Chèvre Inconjugué ELISA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tag probed with ABIN1590101 (0.1 µg/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with ABIN1590101 (0.1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: PIM2 Antibody [NBP2-26115] - HEK293 lysate (10 ug protein in RIPA buffer) overexpressing Human PIM2 with C-terminal MYC tag probed with NBP2-26115 (0.1 ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with NBP2-26115 (0.1 mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. Immunohistochemistry-Paraffin: PIM2 Antibody  - 5ug/ml staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$485.88
Détails
Humain Chèvre Inconjugué ELISA, IHC, IHC (p), WB Human, Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Human, Heart: Formalin-Fixed Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails

anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) Anticorps mieux référencés

  1. Human Polyclonal PIM2 Primary Antibody pour ICC, IF - ABIN4345625 : Santio, Vahakoski, Rainio, Sandholm, Virtanen, Prudhomme, Anizon, Moreau, Koskinen: Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. dans Molecular cancer 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal PIM2 Primary Antibody pour IHC (p), IP - ABIN392442 : Pogacic, Bullock, Fedorov, Filippakopoulos, Gasser, Biondi, Meyer-Monard, Knapp, Schwaller: Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. dans Cancer research 2007 (PubMed)

  3. Human Polyclonal PIM2 Primary Antibody pour ELISA, WB - ABIN4345628 : Hammerman, Fox, Cinalli, Xu, Wagner, Lindsten, Thompson: Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation. dans Cancer research 2004 (PubMed)

  4. Human Polyclonal PIM2 Primary Antibody pour ELISA, WB - ABIN4345627 : Morishita, Katayama, Sekimizu, Tsuruo, Fujita: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. dans Cancer research 2008 (PubMed)

Plus d’anticorps contre Proto-Oncogene Pim-2 (Serine Threonine Kinase) partenaires d’interaction

Zebrafish Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. Inhibition of the Pim1 (Montrer PIM1 Anticorps) oncogene (Montrer RAB1A Anticorps) results in diminished visual function.

Human Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. Inhibition of PIM2 attenuated asthma symptoms and increased expression levels of interleukin (IL)10 (Montrer IL10 Anticorps) and forkhead box (Montrer FOXO Anticorps) protein 3 (Montrer HSPB3 Anticorps) (FOXP3 (Montrer FOXP3 Anticorps)) in bronchoalveolar lavage fluid.

  2. data suggest that PIM1 (Montrer PIM1 Anticorps)/2 kinase overexpression is a common feature of male reproductive organs tumors, which provoke tissue alterations and a large inflammatory response that may act synergistically during the process of tumorigenesis.

  3. show that PIM1 (Montrer PIM1 Anticorps) contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 (Montrer PIM3 Anticorps) could also influence the outcome.

  4. the elevated expression of PIM2 in blastic cells is associated with poor prognosis of AML (Montrer RUNX1 Anticorps) patients and their resistance to induction therapy.

  5. Our data provide evidence for a novel role for Pim2 in the regulation of the DNA damage response (DDR (Montrer DDR1 Anticorps)). Knockdown of Pim2 upregulates several downstream DDR (Montrer DDR1 Anticorps) markers, mimicking the effects of doxorubicin (Dox) treatment of MM cells, and suggesting a role for the kinase as a negative regulator of this pathway.

  6. These results demonstrate the involvement of PIM (Montrer PIM1 Anticorps) kinases in LIF (Montrer LIF Anticorps)-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.

  7. PIM (Montrer PIM1 Anticorps) kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival.

  8. High PIM2 expression is associated with osteosarcoma.

  9. We show that Pim2 inhibitors and proteasome inhibitors, such as bortezomib, have additive effects to inhibit the growth of myeloma cells, suggesting that Pim2 could be an interesting target for the treatment of multiple myeloma.

  10. PIM2 gene knockdown enhances the anti-proliferative effect of AZD1208 in non-Hodgkin lymphoma cell line.

Mouse (Murine) Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. studies define a pathway for limiting the regulation of Foxp3 (Montrer FOXP3 Anticorps) function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses

  2. Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells.

  3. Loss of PIM2 is associated with abnormal hematopoietic phenotypes.

  4. signals from IL-7 (Montrer IL7 Anticorps) and RAG DSBs activate distinct Pim (Montrer PIM1 Anticorps) kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.

  5. Targeting cap-dependent translation blocks converging survival signals by AKT (Montrer AKT1 Anticorps) and PIM 1 (Montrer PIM1 Anticorps), 2 kinases in lymphoma

  6. PIM2 controls the expression of the pro-inflammatory cytokine IL-6 (Montrer IL6 Anticorps).

  7. results support the hypothesis that Pim2, which is also a known target of Flt3 (Montrer FLT3 Anticorps)-ITD (another gene that cooperates with PML (Montrer PML Anticorps)-RARalpha (Montrer RARA Anticorps)), cooperates with PRalpha to induce acute promyelocytic leukemia (Montrer PML Anticorps)-like disease

  8. Pim-2 is a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival

  9. pim-2 functions similarly to pim-1 (Montrer PIM1 Anticorps) as a pro-survival kinase; BAD is a legitimate PIM-2 substrate

  10. Pim-2 and Akt-1 (Montrer AKT1 Anticorps) are critical components of overlapping but independent pathways, either of which is sufficient to promote the growth and survival of nontransformed hematopoietic cells

Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) profil antigène

Profil protéine

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.

Gene names and symbols associated with PIM2

  • Pim-2 proto-oncogene, serine/threonine kinase (pim2) anticorps
  • Pim-2 proto-oncogene, serine/threonine kinase (PIM2) anticorps
  • Pim-2 proto-oncogene, serine/threonine kinase (Pim2) anticorps
  • proviral integration site 2 (Pim2) anticorps
  • cb1068 anticorps
  • DXCch3 anticorps
  • fj47b05 anticorps
  • Pim-2 anticorps
  • pim2 anticorps
  • wu:fj47b05 anticorps

Protein level used designations for PIM2

kinase pim-1 , proviral integration site 2 , serine/threonine-protein kinase Pim-1 , serine/threonine-protein kinase pim-2 , pim-2h , proto-oncogene Pim-2 (serine threonine kinase) , serine/threonine protein kinase pim-2 , serine/threonine kinase

GENE ID SPECIES
58054 Danio rerio
11040 Homo sapiens
442959 Canis lupus familiaris
508424 Bos taurus
317366 Rattus norvegicus
473600 Pan troglodytes
18715 Mus musculus
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