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Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. De plus, nous expédions RNF2 Protéines (7) et RNF2 Kits (2) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal RNF2 Primary Antibody pour ChIPSeq, ChIP - ABIN2668629
Basu, Wilkinson, Colavita, Fennelly, Atchison: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. dans Nucleic acids research 2014
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Human Monoclonal RNF2 Primary Antibody pour RNAi, ELISA - ABIN562662
Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Polyclonal RNF2 Primary Antibody pour IHC, IHC (p) - ABIN4350772
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. dans PLoS genetics 2013
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Human Polyclonal RNF2 Primary Antibody pour ELISA, WB - ABIN268569
Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. dans Molecular and cellular biology 2002
Observations demonstrated that Plk1 directly interacts with RNF2 and degrades RNF2 via the ubiquitindependent degradation pathway. RNF2 may be used as a new target for mitotic regulation and tumorigenesis.
These data suggest that RNF2 is an important upstream negative regulator of SIK1 (Montrer SIK1 Anticorps) and that restoration of SIK1 (Montrer SIK1 Anticorps) levels induced by loss of RNF2 inhibited HCC (Montrer FAM126A Anticorps) cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC (Montrer FAM126A Anticorps) treatment.
Study found that prostate cancer (PCa (Montrer FLVCR1 Anticorps)) tissues have high RNF2 expression which is positively correlated with tumor grade indicating that RNF2 may have oncogenic function in PCa (Montrer FLVCR1 Anticorps).
Our findings identify RING1B as a trait of the cell-of-origin in Ewing sarcoma
Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.
overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.
Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.
O-GlcNAc (Montrer OGT Anticorps) modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.
The enzymatic activity of BMI1 (Montrer BMI1 Anticorps) and RING1B were evaluated and compared.
Bmi1 (Montrer BMI1 Anticorps) and possibly RNF2 may be attractive biomarkers of gemcitabine resistance in the context of RRM1 (Montrer RRM1 Anticorps) expression.
Data show that RNF2 promotes STAT1 (Montrer STAT1 Anticorps)/STAT2 (Montrer STAT2 Anticorps) disassociation from DNA.
the ability of RING1B, a core component of PRC1 (Montrer PRC1 Anticorps), to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 (Montrer PRC1 Anticorps)
RNF2 associates with AMBRA1 (Montrer AMBRA1 Anticorps) to act as an E3 ligase to ubiquitinate AMBRA1 (Montrer AMBRA1 Anticorps) via K48 linkage.
The polycomb (Montrer CBX2 Anticorps) component Ring1B regulates the timed termination of Fezf2 (Montrer FEZF2 Anticorps) expression and thus subcerebral projection neuron production during mouse neocortical development.
Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a (Montrer CDKN1A Anticorps) and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.
Af9 (Montrer MLLT3 Anticorps) mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC (Montrer SCNN1A Anticorps) promoter to constrain basal alpha-ENaC (Montrer SCNN1A Anticorps) transcription in collecting duct cells.
Ring1b mediates Meis2 (Montrer MEIS2 Anticorps) promoter and midbrain-specific enhancer association.
Aurora B (Montrer AURKC Anticorps) and Ring1B co-occupy active promoters in resting lymphocytes.
Fbxl10 (Montrer KDM2B Anticorps) has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.
identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 (Montrer RING1 Anticorps) and Rnf2, two central components of the Polycomb (Montrer CBX2 Anticorps) repressive complex 1 (PRC1 (Montrer PRC1 Anticorps))
The polycomb group protein (Montrer CBX4 Anticorps) ring1b/rnf2 is specifically required for craniofacial development.
These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
E3 ubiquitin-protein ligase RING2
, HIP2-interacting protein 3
, RING finger protein 1B
, RING finger protein BAP-1
, huntingtin-interacting protein 2-interacting protein 3
, protein DinG
, ring finger protein 1b