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SMOC2 encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. De plus, nous expédions SMOC2 Kits (5) et et beaucoup plus de produits pour cette protéine.
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Smoc2 modulates embryonic myelopoiesis during zebrafish development.
SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders.
SMOC2 was highly expressed in both peritoneal and endometrioma lesions. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue.
The expression of Smoc2 was significantly higher in hepatocellular carcinoma (HCC) tissues compared with corresponding non-tumor liver tissues. Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression.
L1-mediated CRC progression involves the acquisition of a stem cell-like phenotype, and that SMOC-2 elevation is necessary for L1-mediated induction of more aggressive/invasive CRC properties.
could not detect an association between SMOC2 gene and AMD. This study tests the candidacy of SMOC2 gene to the etiology of AMD
SMOC2 SNP may play a role in autoimmune thyroid disease susceptibility as a dominant polymorphism.
mutation in exon 8 of the SMOC2 gene linked to oligodontia
Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects
The variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients.
SMOC2 is a risk locus for generalized vitiligo and perhaps other autoimmune diseases
identification of gene, chromosome mapping
SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors
We tested association between SMOC2 polymorphisms and FEV(1) and FVC. SMOC2 might play an important role in the determination of FEV(1) and FVC
Although this study specifies rat, the authors studied and discussed the human gene in this study as well.
By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells
SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
SMOC-2 contributes to cell cycle progression by maintaining ILK activity during G1.
SMOC-2, like other members of the BM40/SPARC family, acts as a regulator of cell-matrix interactions.
results indicate that Smoc2 is a novel transcriptional target of activated Ahr. Perturbation of Smoc2 expression may mediate the adverse developmental effects of environmental aryl-hydrocarbon exposure
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants.
SPARC-related modular calcium-binding protein 2
, secreted modular calcium-binding protein 2
, SPARC related modular calcium binding 2
, SPARC-related modular calcium-binding protein 2-like
, smooth muscle associated protein 2
, smooth muscle-associated protein 2
, thyroglobulin type-1 repeat containing protein