The protein encoded by is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. De plus, nous expédions et SSB Protéines (21) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
20823 P32067
6741 P05455
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Top SSB Kits ELISA sur

Showing 6 out of 14 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests 15 to 18 Days
Souris 0.057 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 15 to 17 Days
Rat 29 ng/mL 78.12 pg/mL - 5000 pg/mL   96 Tests 15 to 17 Days
Veuillez renseigner 96% n/a   96 Tests 4 to 6 Days
Boeuf (Vache)
  96 Tests 15 to 18 Days
Veuillez renseigner
  10 reactions 4 to 6 Days

Plus Kits ELISA pour SSB partenaires d'interaction

Mouse (Murine) SSB interaction partners

  1. La deletion is associated with Neuron Death and Reactive Astrocytosis.

  2. Data indicate that La antigen (Sjogren's syndrome antigen B) is essential in different cell types and required for normal development of various tissue types.

  3. Overexpression of mouse or human La enhanced M-MuLV particle release in the absence of glycosylated gag.

  4. Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.

  5. Blastocysts derived from La+/- intercrosses yielded 38 La+/+ and La+/- embryonic stem (ES) cell lines but no La-/- ES cell lines, suggesting that La contributes a critical function toward the establishment or survival of ES cells.

  6. Overexpression of La autoantigen is associated with lymphoma

  7. truncation of La alters the immunodominance hierarchy of T cell responsiveness to hLa and may be a factor in the initiation or maintenance of anti-La autoimmunity.

  8. La appears to be an important contributor to Akt-mediated translational regulation of these transcripts in murine glial cells.

Human SSB interaction partners

  1. Data is consistent with human La functioning in translation through contacts to the poly(A) tail.

  2. Sumoylation of La protein promotes cell proliferation by averting ubiquitination-mediated degradation of the STAT3 protein.

  3. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA.

  4. our data support a novel model, whereby cancer-associated La protein contributes to cisplatin resistance by stimulating the translation of anti-apoptotic factor Bcl2 in HNSCC cells.

  5. La protein is an important microprocessor component regulating miRNA processing efficiency by association with DGCR8 to regulate formation of the DGCR8-Drosha complex for miRNA processing.

  6. La functions as gatekeeper ensuring correct tRNA maturation and protecting the miRNA pathway from potentially functional tRNA fragments.

  7. Findings identified two novel SUMO acceptors sites on La and suggest that sumoylation of La alters its RNA-binding activity, which could influence a broad range of RNA processing steps where La's function has been implicated.

  8. Binding of double-stranded RNA involves less penetration into the RNA recognition motif (RRM2) binding pocket and more engagement with the unstructured C-terminus of the La C-terminal domain (CTD).

  9. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La.

  10. At the 3' UTR, HUR facilitates circularization of the viral genome through interaction with another host factor, La, which is critical for replication.

  11. Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the SS-A and SS-B autoantigens in salivary gland epithelial cells of Sjogren's syndrome patients.

  12. expression of nuclear hLa Ag induces thymic clonal deletion and tTreg selection, and lymphocytic infiltration of the lung is a consequence of La-specific CD4(+) T cell autoimmunity

  13. Authors provide a model whereby a novel interplay between RNA-binding, RNA chaperoning and AKT phosphorylation of La protein regulates CCND1 IRES-mediated translation.

  14. Primary Sjogren's patients with WSP form a benign subgroup, with a lower prevalence of anti-SSB and extraglandular manifestations.

  15. A beta turn in the human La protein is responsible for the interaction with the hepatitis C virus RNA.

  16. Total IgG levels correlate positively with autoantibodies La, Ro60 and Ro52 but not with RING or B-box domain antibodies of Ro52.

  17. The competition between the host factor (La) and the viral protein (NS3) for binding to HCV IRES might regulate the molecular switch from translation to replication of HCV.

  18. Our study demonstrates that La plays a critical role in regulating HCV replication by interacting with the GCAC motif.

  19. Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition

  20. Iron promotes the translation initiation of hepatitis C virus by stimulating the expression of eIF3A and La proteins.

SSB profil antigène

Antigen Summary

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.

Gene names and symbols associated with SSB Kits ELISA

  • Sjogren syndrome antigen B (Ssb) anticorps
  • Sjogren syndrome antigen B (SSB) anticorps
  • Sjogren syndrome antigen B L homeolog (ssb.L) anticorps
  • single stranded DNA binding protein 1 (SSBP1) anticorps
  • La anticorps
  • lab1 anticorps
  • larp3 anticorps
  • Mt-SSB anticorps
  • MtSSB anticorps
  • SS-B anticorps
  • ssb anticorps
  • Ssbp1 anticorps

Protein level used designations for SSB Kits ELISA

La protein , Lupus LA protein homolog (LA ribonucleoprotein) (LA autoantigen homolog) , autoantigen La , la autoantigen homolog , la ribonucleoprotein , lupus La protein homolog , mRNA for autoantigen , La ribonucleoprotein domain family, member 3 , SS-B , SS-B/La protein , la autoantigen , lupus La antigen , lupus La protein , sjoegren syndrome type B antigen , la autoantigen homolog B , la ribonucleoprotein B , lupus La protein homolog B , single-stranded DNA binding , single-stranded DNA-binding protein, mitochondrial

20823 Mus musculus
81783 Rattus norvegicus
6741 Homo sapiens
478787 Canis lupus familiaris
338071 Bos taurus
379324 Xenopus laevis
100008866 Oryctolagus cuniculus
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