Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) Kits ELISA

SMG6 encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of SMG6 also participates in the nonsense-mediated mRNA decay (NMD) pathway. De plus, nous expédions SMG6 Anticorps (12) et et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SMG6 103677 P61406
SMG6 23293 Q86US8
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
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Plus Kits ELISA pour SMG6 partenaires d'interaction

Mouse (Murine) Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) interaction partners

  1. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.

Human Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG6) interaction partners

  1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.

  2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.

  3. A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets.

  4. SMG6 requires UPF1 and SMG1 for nonsense-mediated mRNA decay.

  5. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

  6. Consistent with involvement of SMG6 in the decay process full-length nonsense-containing beta-globin mRNA was increased and the Delta169 decay intermediate was decreased in cells knocked down for SMG6.

  7. The tricotetrapeptide repeat-containing domain within Est1A was sufficient for interaction with hTERT.

  8. Data show that SMG6 interacts directly with the EJC via two conserved EJC-binding motifs (EBMs).

  9. associated with most or all active telomerase in HeLa cell extracts; overexpression of hEST1A induces anaphase bridges due to chromosome-end fusions, and telomeric DNA persists at the fusion points

  10. Human EST1A is associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping.

  11. Structural properties of the PIN domain indicate its putative active center consisting of invariant acidic amino acid residues, which is similar to the active center of 5' nucleases.

  12. Report shows that hEST1A assembles specifically with telomerase in the context of the telomerase RNA (hTR)-hTERT ribonucleoprotein, through the high affinity of hEST1A for hTR and specific protein-protein contacts with hTERT.

SMG6 profil antigène

Antigen Summary

This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC)\; interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMG6

  • Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg6) anticorps
  • SMG6, nonsense mediated mRNA decay factor (SMG6) anticorps
  • AI317223 anticorps
  • AU041178 anticorps
  • C17orf31 anticorps
  • EST1A anticorps
  • hSMG5/7a anticorps
  • SMG-6 anticorps

Protein level used designations for SMG6

EST1-like protein A , ever shorter telomeres 1A , telomerase subunit EST1A , telomerase-binding protein EST1A , EST1 telomerase component homolog A , smg-6 homolog, nonsense mediated mRNA decay factor

GENE ID SPECIES
103677 Mus musculus
100172632 Pongo abelii
23293 Homo sapiens
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