Plus produit pour Sorbitol Dehydrogenase ELISA Kit
Plus Kits ELISA pour Sorbitol Dehydrogenase partenaires d'interaction
Mouse (Murine) Sorbitol Dehydrogenase (SORD) interaction partners
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flavonoids induced marked improvement in paw licking time, paw edema %, malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities, with slight progress in paw interlukin-1beta. Additionally, silymarin augmented brain content of dopamine and norepinephrine.
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Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis.
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Knockout mice had the highest sorbitol content among various genetic types including mice wwith human aldose reductase.
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Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
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The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
Human Sorbitol Dehydrogenase (SORD) interaction partners
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SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level.
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One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways.
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The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin and oral diabetic groups.
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Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes.
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The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.
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crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees
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Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.
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Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.
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The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
Sorbitol Dehydrogenase (SORD) profil antigène
Antigen Summary
Sorbitol dehydrogenase (SORD\; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1\; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995
Gene names and symbols associated with SORD
- sorbitol dehydrogenase L homeolog (sord.L) anticorps
- sorbitol dehydrogenase (sord) anticorps
- sorbitol dehydrogenase (Sdh) anticorps
- sorbitol dehydrogenase (LOC733025) anticorps
- sorbitol dehydrogenase (polS) anticorps
- sorbitol dehydrogenase (RS_RS10765) anticorps
- sorbitol dehydrogenase (sdh) anticorps
- sorbitol dehydrogenase (smoS) anticorps
- sorbitol dehydrogenase (Rsph17029_1731) anticorps
- Sorbitol dehydrogenase (Srd) anticorps
- sorbitol dehydrogenase (RSKD131_1411) anticorps
- sorbitol dehydrogenase (Sord) anticorps
- sorbitol dehydrogenase (SORD) anticorps
- BmSDH anticorps
- MGC83437 anticorps
- PSPTO0363 anticorps
- SDH anticorps
- Sdh-1 anticorps
- Sdh1 anticorps
- SODH-1 anticorps
- sord anticorps
- SORD1 anticorps
Protein level used designations for SORD
sorbitol dehydrogenase , L-iditol 2-dehydrogenase , mammalian sorbitol dehydrogenase homolog , sorbitol dehydrogenase 1
GENE ID | SPECIES |
---|---|
446317 | Xenopus laevis |
496715 | Xenopus (Silurana) tropicalis |
692742 | Bombyx mori |
733025 | Bombyx mori |
1181972 | Pseudomonas syringae pv. tomato str. DC3000 |
1220989 | Ralstonia solanacearum GMI1000 |
3690081 | Burkholderia pseudomallei 1710b |
3719926 | Rhodobacter sphaeroides 2.4.1 |
4897512 | Rhodobacter sphaeroides ATCC 17029 |
5656982 | Drosophila melanogaster |
7358398 | Rhodobacter sphaeroides KD131 |
9746093 | Halomonas elongata DSM 2581 |
20322 | Mus musculus |
6652 | Homo sapiens |
415332 | Gallus gallus |
487535 | Canis lupus familiaris |
24788 | Rattus norvegicus |
101115280 | Ovis aries |
508954 | Bos taurus |
100158181 | Sus scrofa |
100173784 | Pongo abelii |
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