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Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. De plus, nous expédions Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Protéines (13) et Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) Kits (9) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal SDHB Primary Antibody pour ICC, IF - ABIN4352356
van Nederveen, Gaal, Favier, Korpershoek, Oldenburg, de Bruyn, Sleddens, Derkx, Rivière, Dannenberg, Petri, Komminoth, Pacak, Hop, Pollard, Mannelli, Bayley, Perren, Niemann, Verhofstad, de Bruïne et al.: An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. ... dans The Lancet. Oncology 2009
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Human Polyclonal SDHB Primary Antibody pour WB - ABIN1881781
Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2010
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Human Polyclonal SDHB Primary Antibody pour ICC, IF - ABIN4352351
Morton, Beltram, Carter, Michailidou, Gorjanc, McFadden, Barrios-Llerena, Rodriguez-Cuenca, Gibbins, Aird, Moreno-Navarrete, Munger, Svenson, Gastaldello, Ramage, Naredo, Zeyda, Wang, Howie, Saari et al.: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. ... dans Nature medicine 2016
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Human Polyclonal SDHB Primary Antibody pour ELISA, WB - ABIN269796
Selak, Armour, MacKenzie, Boulahbel, Watson, Mansfield, Pan, Simon, Thompson, Gottlieb: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. dans Cancer cell 2005
Cow (Bovine) Polyclonal SDHB Primary Antibody pour WB - ABIN2783181
Cascón, Landa, López-Jiménez, Díez-Hernández, Buchta, Montero-Conde, Leskelä, Leandro-García, Letón, Rodríguez-Antona, Eng, Neumann, Robledo: Molecular characterisation of a common SDHB deletion in paraganglioma patients. dans Journal of medical genetics 2008
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sdhB mutant is hypersensitive to oxygen and displays hallmarks of a progeroid syndrome
The overall penetrance of succinate dehydrogenase B (SDHB) mutations is estimated to be 21% at age 50 and 42% at age 70 when adequately corrected for ascertainment.
Germline SDHB mutation is associated with Pheochromocytoma and Paraganglioma.
Data suggest that low expression of SDHB in metastatic lesions is associated with longer overall survival in patients with advanced ileal well-differentiated neuroendocrine tumors with lymph node or liver metastases.
Results identified a high frequency of germline mutation in SDHB gene in patients presenting with bladder paraganglioma.
automation, reproducibility, and cost efficiency of SDHB IHC offer advantages over the labor-intensive histochemical method requiring frozen sections
We report a unique case of an SDH (Montrer SARDH Anticorps)-deficient GIST case with an activating PDGFRA (Montrer PDGFRA Anticorps) mutation. Oncogenic mutations in GIST are generally mutually exclusive; however documented exceptions exist which may have diagnostic and therapeutic implications.
Mutation in the SDHB gene is associated with mediastinal paraganglioma.
We report for the first time the presence of both TFE3 (Montrer TFE3 Anticorps) translocation and SDHB mutation in the same renal cell carcinoma (Montrer MOK Anticorps) tumor.
Heterozygous germ line mutations in SDHB neutrophil survival is independent of HIF-1alpha (Montrer HIF1A Anticorps) expression and linked to uncoupling of the mitochondrial electron transport chain.
miR (Montrer MLXIP Anticorps)-142-5p up-regulation in colorectal cancer probably facilitates generation of aerobic glycolysis by reducing SDHB expression.
tissue expression analysis indicated that that swine SDHB, SNRPA (Montrer SNRPA Anticorps) and CRYBB1 (Montrer CRYBB1 Anticorps) gene were differentially expressed in tissues including fat, lung, muscle, small intestine, kidney, large intestine, spleen and liver
Data show that lack of succinate dehydrogenase (SDH (Montrer SDHA Anticorps)) activity commits cells to consume extracellular pyruvate.
Using Sdhb(+/-) mice, we provide evidence that pituitary hyperplasia in SDHx-deficient cells may be the initial abnormality in the cascade of events leading to pituitary adenoma formation.
Tumor-derived FH and SDH (Montrer SDS Anticorps) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (Montrer HELLS Anticorps).
Data show that two subunits of complex II (succinate dehydrogenase (Montrer SDHD Anticorps), or SDH (Montrer SDS Anticorps)), SDHA (Montrer SDHA Anticorps) and SDHB, interacted specifically with SIRT3 (Montrer SIRT3 Anticorps).
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
, succinate dehydrogenase complex subunit B
, COMPLEX II: iron-sulfur subunit
, iron-sulfur protein subunit of succinate dehydrogenase
, succinate dehydrogenase
, succinate dehydrogenase B
, succinate dehydrogenase Iron-sulfur
, succinate dehydrogenase Iron-sulfur protein
, succinate dehydrogenase iron protein
, succinate dehydrogenase subunit b
, iron-sulfur subunit of complex II
, Iron-sulfur subunit of complex II