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Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.
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Human TFF3 Kit ELISA pour Sandwich ELISA - ABIN414858
Huang, Zhang, Lu, Wu, Wang, Zhang, Ding: Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China. dans BMC gastroenterology 2014
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High TFF3 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma.
Results indicate diagnostic biomarker potential of Trefoil factor 3 (TFF3) promoter hypomethylation for prostate cancer (PC) as well as prognostic biomarker potential of TFF3 RNA expression.
ITF role in promoting intestinal epithelial cells migration through crosstalk between the ERK (Montrer EPHB2 Kits ELISA) and JAK (Montrer JAK3 Kits ELISA)/STAT3 (Montrer STAT3 Kits ELISA) pathways
TFF3 levels were significantly elevated in patients with stage I (p= 0.001) and T1 gastric cancer (p= 0.013).
hTFF3 exhibits self-induction action, and that STAT3 (Montrer STAT3 Kits ELISA) is the key transcription factor to maintain the function of self-induction.
The present study demonstrated a negative association between the expression of miR75p and TFF3 in IBD lesional tissues and normal tissues. In conclusion, TFF3 was identified as a novel target of miR75p
trefoil factors family 3 may have a role in colorectal cancer
This study provides the first evidence that TFF3 is locally elevated in the peritoneal cavity in endometriosis and might play a role in disease pathogenesis and its associated inflammatory processes. Furthermore, the results show that TFF3 is regulated through the menstrual cycle.
involvement of TFF3 in the pathogenesis of rhonchopathy and OSA
Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 (Montrer DEFB4 Kits ELISA) and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.(
These studies reveal a new link between hepatic GALE (Montrer GALE Kits ELISA) activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression.
the Tg(Tff1 (Montrer TFF1 Kits ELISA)-CreERT2;Tff2 (Montrer TFF2 Kits ELISA)-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases
TFF3 is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia.
TFF1 (Montrer TFF1 Kits ELISA) and TFF3 peptides might be involved in the complex processes of nervous system development and differentiation and brain plasticity.
The TFF3 was present in cartilage chondrocytes undergoing endochondral ossification, particularly in zone of proliferation, hypertrophy and calcification as well as in zone of cartilage degeneration during the monitored fetal period.
Intravenous administration of recombinant TFF3 reversed changes in cerebral injury.
Tff3 peptides are involved in glucose homeostasis and insulin (Montrer INS Kits ELISA) sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with type 2 diabetes mellitus.
The genetically deleting Tff3 in mice altered down-regulated Pttg1 (Montrer PTTG1 Kits ELISA) and up-regulated serpina3n (Montrer SERPINA3N Kits ELISA) expression, indicating a potential role of these factors during the development of presbyacusis.
Tff3 knock out mice have lower body weight than wild-type mice.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
trefoil factor 3 (intestinal)
, intestinal trefoil factor
, trefoil factor 3
, Intestinal trefoil factor
, trefoil factor family peptide 3
, polypeptide P1.B