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Tff3 deficiency affects the profile and accumulation of fatty acids in the liver, with no obvious oxidative stress increase, although expression/activity of monitored enzymes is changed as well as the level of SIRT1 and PPARgamma protein.
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The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation
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These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression.
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Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.(
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the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases
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TFF3 is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia.
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TFF1 and TFF3 peptides might be involved in the complex processes of nervous system development and differentiation and brain plasticity.
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The TFF3 was present in cartilage chondrocytes undergoing endochondral ossification, particularly in zone of proliferation, hypertrophy and calcification as well as in zone of cartilage degeneration during the monitored fetal period.
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Intravenous administration of recombinant TFF3 reversed changes in cerebral injury.
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Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with type 2 diabetes mellitus.
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The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis.
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Tff3 knock out mice have lower body weight than wild-type mice.
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Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-induced colitis.
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results suggest that a diminution of the intestinal trefoil factor system may be involved in the acceleration of aging in SAM-P6 mice
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Loss of the barrier protective molecule TFF3 leads to a profound increase in susceptibility to DSS-induced colitis, and this can be abrogated by reducing Fuc-TVII-dependent leukocyte recruitment.
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gene activation mediated by SHP2 and STAT pathways in gp130 mutant mice
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TFF3 overexpression may be a critical process in mouse and human hepatocellular carcinogenesis
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The data underline a direct role for Aire in tissue-restricted antigens expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity.
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the expression of mucins 1 to 4 and trefoil factor 3 was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
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reveal a pivotal role for Tff3 in corneal wound healing mechanism and have broad implications for developing novel therapeutic strategies for treating nonhealing wounds
