anti-phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Anticorps

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

2. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis.

3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)

4. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

5. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

6. The sites on Nef and the PACS proteins required for their interaction, are identified.

7. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

8. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2

9. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

10. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

11. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

12. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

2. PACS-2 coordinates p53/p21- dependent cell cycle arrest with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.

3. CS-2 traffics to the nucleus where it regulates SIRT1-mediated p53 deacetylation. PACS-2 binds SIRT1 in vitro and directly inhibits SIRT1-catalyzed p53 deacetylation.

4. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

5. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.