anti-phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Anticorps

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. De plus, nous expédions PACS2 Protéines (4) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PACS2 23241 Q86VP3
PACS2 217893  
PACS2    
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Top anti-PACS2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 28 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PACS2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: A549 cell lysate 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of human brain tissue, using PACS2-Specific antibody. ABIN6273285 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$616.00
Détails
Humain Lapin Inconjugué ELISA, IF, IHC (p), WB   0.1 mg 2 to 3 Days
$360.00
Détails
Humain Lapin Inconjugué IHC (p) Immunohistochemical staining of human liver with PACS2 polyclonal antibody  shows strong cytoplasmic positivity in hepatocytes at 1:50-1:200 dilution. 100 μL 11 to 12 Days
$577.33
Détails
Humain Lapin Biotin IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin APC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin FITC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin PE IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails

anti-PACS2 Anticorps mieux référencés

  1. Human Polyclonal PACS2 Primary Antibody pour IHC, IHC (p) - ABIN4343360 : Aslan, You, Williamson, Endig, Youker, Thomas, Shu, Du, Milewski, Brush, Possemato, Sprott, Fu, Greis, Runckel, Vogel, Thomas: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. dans Molecular cell 2009 (PubMed)

Plus d’anticorps contre PACS2 partenaires d’interaction

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

  2. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis.

  3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)

  4. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

  5. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

  6. The sites on Nef and the PACS proteins required for their interaction, are identified.

  7. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

  8. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2

  9. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

  10. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

  11. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

  12. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

  2. PACS-2 coordinates p53/p21- dependent cell cycle arrest with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.

  3. CS-2 traffics to the nucleus where it regulates SIRT1-mediated p53 deacetylation. PACS-2 binds SIRT1 in vitro and directly inhibits SIRT1-catalyzed p53 deacetylation.

  4. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

  5. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

PACS2 profil antigène

Profil protéine

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Gene names and symbols associated with PACS2

  • phosphofurin acidic cluster sorting protein 2 (PACS2) anticorps
  • phosphofurin acidic cluster sorting protein 2 (Pacs2) anticorps
  • 6720425G15Rik anticorps
  • AW208651 anticorps
  • AW489976 anticorps
  • E230011J22 anticorps
  • mKIAA0602 anticorps
  • PACS-2 anticorps
  • Pacs1l anticorps

Protein level used designations for PACS2

PACS1-like protein , PACS-2

GENE ID SPECIES
23241 Homo sapiens
217893 Mus musculus
Fournisseurs de qualité sélectionnés pour anti-PACS2 (PACS2) Anticorps
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