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anti-Human ITCH Anticorps:
anti-Mouse (Murine) ITCH Anticorps:
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Human Monoclonal ITCH Primary Antibody pour IF, WB - ABIN968414
Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. dans Nature genetics 1998
Human Polyclonal ITCH Primary Antibody pour ELISA, WB - ABIN261096
Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. dans Nature cell biology 2006
Human Polyclonal ITCH Primary Antibody pour ICC, IF - ABIN4327763
Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. dans International journal of cancer 2013
JunB (Montrer JUNB Anticorps) neddylation mediated by Itch promotes its ubiquitination-dependent degradation.
Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Data show that the E3 ubiquitin ligase (Montrer MUL1 Anticorps) Itch forms a complex with tricellulin (Montrer MARVELD2 Anticorps) and thereby enhances its ubiquitination.
ASPP2 (Montrer TP53BP2 Anticorps) suppresses invasion, peritoneal dissemination and TGF-beta1 (Montrer TGFB1 Anticorps)-induced EMT (Montrer ITK Anticorps) by inhibiting Smad7 (Montrer SMAD7 Anticorps) degradation mediated by ITCH in gastric cancer cells.
WBP2 (Montrer WBP2 Anticorps)/ITCH signaling functions to link the intricate Wnt (Montrer WNT2 Anticorps) and Hippo signaling networks in breast cancer.
The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (Montrer RBM9 Anticorps) induced degradation of vFLIP.
Results indicate that TAX1BP1 (Montrer TAX1BP1 Anticorps) functions as an adaptor molecule for Itch to target MAVS (Montrer MAVS Anticorps) during RNA virus infection and thus restrict virus-induced apoptosis.
These data demonstrate that Itch, ubiquitin, and Alix (Montrer PDCD6IP Anticorps) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.
The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain (Montrer DRP2 Anticorps) of the host E3 ubiquitin ligase (Montrer MUL1 Anticorps) ITCH.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
this study identified a previously unknown role for Itch in regulating IL-17 (Montrer IL17A Anticorps)-mediated colonic inflammation and carcinogenesis
Itch monoubiquitinates SMN (Montrer STMN1 Anticorps) and monoubiquitination of SMN (Montrer STMN1 Anticorps) plays an important role in regulating its cellular localization.
ITCH targets TXNIP (Montrer TXNIP Anticorps) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (Montrer TXN Anticorps) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (Montrer TNF Anticorps) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (Montrer TNF Anticorps) signaling is genetically deleted.
ITCH modulates SIRT6 (Montrer SIRT6 Anticorps) and SREBP2 (Montrer SREBF2 Anticorps) to influence lipid metabolism and atherosclerosis in ApoE (Montrer APOE Anticorps) null mice
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
The E3 ubiquitin ligase (Montrer MUL1 Anticorps) Itch inhibits p38alpha (Montrer MAPK14 Anticorps) signaling and skin inflammation through the ubiquitylation of Tab1 (Montrer TAB1 Anticorps).
Ndfip1 (Montrer NDFIP1 Anticorps) regulates itch ligase activity and airway inflammation via UbcH7 (Montrer UBE2L3 Anticorps).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (Montrer FOXP3 Anticorps) expression independently of Itch.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy