KEAP1 anticorps (C-Term)

N° du produit ABIN1077378

Détail du produit anti-KEAP1 anticorps

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificité: At least two isoforms of KEAP1 are known to exist.

Purification: Affinity chromatography purified via peptide column

Immunogène: KEAP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1.

Isotype: IgG

Information d'application

Indications d'application: KEAP1 antibody can be used for detection of KEAP1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Commentaires:

(CT) Kelch-like ECH-associated protein 1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C/-20 °C

Stockage commentaire: KEAP1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Date de péremption: 12 months

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1 (KEAP1 Produits)

Synonymes: anticorps INrf2, anticorps KLHL19, anticorps INRF2, anticorps mKIAA0132, anticorps Inrf2, anticorps fb36f11, anticorps keap1, anticorps wu:fb36f11, anticorps KEAP1, anticorps klhl19, anticorps zgc:171654, anticorps kelch like ECH associated protein 1, anticorps kelch-like ECH-associated protein 1, anticorps Kelch-like ECH-associated protein 1, anticorps kelch-like ECH-associated protein 1a, anticorps kelch like ECH associated protein 1 L homeolog, anticorps kelch-like ECH-associated protein 1b, anticorps KEAP1, anticorps Keap1, anticorps keap1a, anticorps keap1, anticorps keap1.L, anticorps keap1b

Sujet: KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-kB activity by targeting IKKbeta degradation. Mutation of the KEAP1 gene is found in lung cancer.
Synonyms: Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2

Poids moléculaire: 69 kDa

ID gène: 9817

NCBI Accession: NP_987096

Pathways: Maintenance of Protein Location