AKAP12 anticorps (C-Term)

N° du produit ABIN1105270

Détail du produit anti-AKAP12 anticorps

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP12 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This anrtibody is expected to recognize both reported isoforms of AKAP12.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence C-KQERESAKSELTES, from the C-Terminus of the protein sequence according to NP_005091.2, NP_653080.1. Genename: AKAP12

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur AKAP12

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Autre désignation: AKAP12 (AKAP12 Produits)

Synonymes: anticorps akap12, anticorps cb27, anticorps esr1, anticorps fb72g12, anticorps id:ibd1202, anticorps sb:cb27, anticorps si:ch73-192g21.1, anticorps wu:fb72g12, anticorps wu:fc21c03, anticorps AKAP12, anticorps AI317366, anticorps SSeCKS, anticorps Srcs5, anticorps Tsga12, anticorps AKAP12A, anticorps AKAP12B, anticorps AKAP12G, anticorps AKAP250, anticorps A kinase (PRKA) anchor protein 12b, anticorps A-kinase anchoring protein 12, anticorps A kinase (PRKA) anchor protein (gravin) 12, anticorps akap12b, anticorps AKAP12, anticorps Akap12

Sujet: Gravin (also known as A Kinase Anchor Protein 12, AKAP12) was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. Antibodies to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain. Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons (NT2 N), Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa and PKA. Decreased binding of PKCa to gravin was found after activation of PKC.Synonyms: A-kinase anchor protein 12, A-kinase anchor protein 250 kDa, AKAP250, Gravin, Myasthenia gravis autoantigen, PRKA12

Poids moléculaire: 191 kDa (NP_005091.2) and 181 kDa (NP_653080.1).

ID gène: 9590

NCBI Accession: NP_005091

Pathways: cAMP Metabolic Process