CD21 anticorps

N° du produit ABIN1106056

Détail du produit anti-CD21 anticorps

Antigène: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD21 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Clone B-ly4 produces mouse IgG1 immunoglobulins directed against a 145 kDa polypeptide of the C3d receptor. Clone B-ly4 was clustered at the Leucocyte Typing Workshop IV [5].

Purification: Affinity chromatography

Clone: B-ly4

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Détails sur CD21

Antigène: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Autre désignation: CD21 (CR2 Produits)

Synonymes: anticorps C3DR, anticorps CD21, anticorps CR, anticorps CVID7, anticorps SLEB9, anticorps Cd21, anticorps cd21, anticorps CR1, anticorps CR1-L, anticorps CR2, anticorps complement C3d receptor 2, anticorps complement C3b/C4b receptor 1 (Knops blood group), anticorps CR2, anticorps Cr2, anticorps CR1

Sujet: The CD21 antigen is expressed on mature B cells, follicular dendritic cells and pharyngeal and cervical epithelial cells [1,2]. CD21, also known as the Complement receptor type 2 (CR2) or Epstein-Barr virus (EBV) receptor, is a receptor for the C3 activation fragments iC3b and C3d. CD21 is part of a multimeric complex on B cells which includes CD19 and CD81 [3]. The ligand for CD21 is generated during activation of complement by the attachment of C3d to potential antigen. This creates fusion proteins that may cross-link the CD19-CD21-CD81 complex to sIg on antigen-specific B cells. The resulting signal transduction lowers the threshold for cellular activation. This enables an antibody reaction to natural protein antigens containing only one or a few epitopes and therefore unable to effectively cross-link Ig molecules on specific B cells. For example, keyhole limpet hemocyanin (KLH) immune complexes can be taken up and processed by all CR2-bearing B cells, regardless of their antigen specificity. KLH immune complexes taken up this way by non-specific B cells were shown to be presented to KLH-specific, MHC class II Th cells. CD23 may also serve as a ligand for CD21 [3].Synonyms: C3DR, C3d receptor, CR2, Complement C3d receptor, Complement receptor type 2, Dendritic Cell Marker, EBV Receptor, Epstein-Barr virus receptor

ID gène: 1380

NCBI Accession: NP_001006659

UniProt: P20023

Pathways: Système du Complément