TLR2 anticorps

N° du produit ABIN7101942

Détail du produit anti-TLR2 anticorps

Antigène: TLR2 (Toll-Like Receptor 2 (TLR2))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR2 est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: Monoclonal antibody mT2.7 reacts with mouse Toll-like receptor 2 (TLR2). The monoclonal antibody mT2.7 stained overexpressed, as well as endogenous cell surface- and intercellular TLR2. The antibody does not affect cell activation through TLR2.

Réactivité croisée (Details): Species reactivity (tested):Mouse.

Purification: Purified

Clone: MTL2-7

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0,1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0,1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TLR2

Antigène: TLR2 (Toll-Like Receptor 2 (TLR2))

Autre désignation: CD282 / TLR2 (TLR2 Produits)

Synonymes: anticorps CD282, anticorps TIL4, anticorps Ly105, anticorps toll like receptor 2, anticorps toll-like receptor 2, anticorps TLR2, anticorps Tlr2, anticorps tlr2

Sujet: Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.Synonyms: Toll-like receptor 2

ID gène: 9606

UniProt: O60603

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades