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CDKN1B anticorps
CDKN1B
Reactivité: Humain, Souris, Rat
WB, IF
Hôte: Souris
Monoclonal
IMD-27
unconjugated
N° du produit ABIN1106657
Détail du produit anti-CDKN1B anticorps
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Antigène
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CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Reactivité
Toutes les réactivités sur CDKN1B Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur CDKN1B Anticorps
Souris
Clonalité
Toutes les clonalités sur CDKN1B Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers CDKN1B Anticorps
Cet anticorp CDKN1B est non-conjugé
Application
Tous les applications à travers CDKN1B Anticorps.
Western Blotting (WB), Immunofluorescence (IF)
Specificité
This antibody reacts to CDKN1B.
Purification
Affinity chromatography
Immunogène
recombinant rodent p27Kip1 protein
Clone
IMD-27
Isotype
IgG1
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Reconstitution
Restore with 1.2 % sodium acetate or neutral PBS
Concentration
0,1 mg/mL
Buffer
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur CDKN1B
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Antigène
CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Autre désignation
CDKN1B / KIP1 (CDKN1B Produits )
Synonymes
anticorps CDKN4, anticorps KIP1, anticorps MEN1B, anticorps MEN4, anticorps P27KIP1, anticorps cdkn1b, anticorps sb:cb611, anticorps wu:fb63g10, anticorps wu:fb64g10, anticorps wu:fe18e03, anticorps CDKN1B, anticorps Kip1, anticorps p27, anticorps FAM14D, anticorps ISG12, anticorps ISG12A, anticorps P27, anticorps Cdki1b, anticorps AA408329, anticorps AI843786, anticorps p27Kip1, anticorps cdkn1bl, anticorps cyclin dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Bb, anticorps interferon alpha inducible protein 27, anticorps cyclin-dependent kinase inhibitor 1B, anticorps cyclin-dependent kinase inhibitor 1Ba, anticorps CDKN1B, anticorps cdkn1bb, anticorps IFI27, anticorps Cdkn1b, anticorps cdkn1ba
Sujet
P27(kip1), also known as cyclin dependent kinase inhibitor 1B(CDKN1B), is a major target of AFX-like forkhead proteins. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper.Phosphorylation leads to the ubiquitination and degradation of CDKN1B. P27(kip1) mapped to 12p13. An increase in p27 causes proliferating cells to exit from the cell cycle, and a decrease in p27 is necessary for quiescent cells to resume division. Abnormally low amounts of p27 are associated with pathological states of excessive cell proliferation, especially cancers. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells.Synonyms: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1
ID gène
1027
NCBI Accession
NP_004055
UniProt
P46527
Pathways
Cycle Cellulaire , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Positive Regulation of Peptide Hormone Secretion , Negative Regulation of Hormone Secretion , Sensory Perception of Sound , Mitotic G1-G1/S Phases , DNA Replication , Positive Regulation of Endopeptidase Activity , Synthesis of DNA , Autophagy
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