GJB2 anticorps (Middle Region)

N° du produit ABIN1107369

Détail du produit anti-GJB2 anticorps

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GJB2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects GJB2 / Cx26 (mid region). No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogène: Peptide mapping at the middle region of rat Connexin 26 .Remarks: Sequence is different from the relative sequence of human by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur GJB2

Antigène: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Autre désignation: GJB2 / Cx26 (GJB2 Produits)

Synonymes: anticorps ppk, anticorps cx26, anticorps dfna3, anticorps dfnb1, anticorps nsrd1, anticorps dfna3a, anticorps dfnb1a, anticorps MGC53062, anticorps connexin-26, anticorps GJB2, anticorps AI325222, anticorps Cnx26, anticorps Cx26, anticorps Gjb-2, anticorps CXN-26, anticorps CX26, anticorps DFNA3, anticorps DFNA3A, anticorps DFNB1, anticorps DFNB1A, anticorps HID, anticorps KID, anticorps NSRD1, anticorps PPK, anticorps gap junction protein beta 2 L homeolog, anticorps gap junction protein beta 2, anticorps gap junction protein, beta 2, anticorps gjb2.L, anticorps GJB2, anticorps Gjb2

Sujet: Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins,called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26 (GJB2) is assigned to human chromosome 13q11-q12. Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.Synonyms: Connexin-26, Gap junction beta-2 protein

ID gène: 2706

NCBI Accession: NP_003995

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization