JUP anticorps
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- Antigène Voir toutes JUP Anticorps
- JUP (Junction Plakoglobin (JUP))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp JUP est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
- Specificité
- The antibody detects Plakoglobin.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, rat. Weakly with mouse.
- Purification
- Protein G
- Clone
- 15F11
- Isotype
- IgG1
- Top Product
- Discover our top product JUP Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- JUP (Junction Plakoglobin (JUP))
- Autre désignation
- Junction Plakoglobin (JUP Produits)
- Synonymes
- anticorps ARVD12, anticorps CTNNG, anticorps DP3, anticorps DPIII, anticorps PDGB, anticorps PKGB, anticorps arvd12, anticorps ctnng, anticorps dp3, anticorps dpiii, anticorps pdgb, anticorps pkgb, anticorps plak, anticorps D930025P04Rik, anticorps PG, anticorps cb80, anticorps danPG, anticorps fb11b06, anticorps jup, anticorps wu:fb11b06, anticorps junction plakoglobin, anticorps junction plakoglobin L homeolog, anticorps Junction plakoglobin, anticorps junction plakoglobin a, anticorps junction plakoglobin S homeolog, anticorps JUP, anticorps Jup, anticorps jup, anticorps jup.L, anticorps Tsp_06656, anticorps plak, anticorps jupa, anticorps jup.S
- Sujet
- Plakoglobin, also known as gamma-catenin belongs together with alpha- and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.Synonyms: CTNNG, Catenin gamma, DP3, Desmoplakin III, Desmoplakin-3, JUP
- ID gène
- 3728
- Pathways
- Cell-Cell Junction Organization, Maintenance of Protein Location
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