RFWD2 anticorps (Middle Region)

N° du produit ABIN1108875

Détail du produit anti-RFWD2 anticorps

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFWD2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MSGLYSPVSE DSTVPQFEAP SPSHSSIIDS TEYSQPPGFS GTSQTKKQPW

Réactivité croisée (Details): Species reactivity (tested):Human, mouse.

Purification: Immunoaffinity column

Immunogène: Synthetic peptide corresponding to a middle region of mouse

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur RFWD2

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Autre désignation: RFWD2 / RNF200 (RFWD2 Produits)

Synonymes: anticorps COP1, anticorps RNF200, anticorps AI316802, anticorps C80879, anticorps Cop1, anticorps RGD1304773, anticorps RFWD2, anticorps cop1, anticorps rnf200, anticorps zgc:163067, anticorps ring finger and WD repeat domain 2, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog, anticorps RFWD2, anticorps Rfwd2, anticorps rfwd2, anticorps rfwd2.L

Sujet: Rfwd2 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It is involved in JUN ubiquitination and degradation and directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Rfwd2 probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.Synonyms: COP1, Constitutive photomorphogenesis protein 1 homolog, E3 ubiquitin-protein ligase RFWD2, RING finger and WD repeat domain protein 2, RING finger protein 200

Poids moléculaire: RFWD2: 80 kDa

ID gène: 26374

NCBI Accession: NM_011931

Pathways: Photoperiodism