ROCK2 anticorps (N-Term)

N° du produit ABIN1108892

Détail du produit anti-ROCK2 anticorps

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROCK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects ROCK2 (N-term).

Réactivité croisée (Details): Species reactivity (expected):MouseSpecies reactivity (tested):Human, rat

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminal of human ROCK2 .Remarks: Sequence is identical to the related rat and mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the lyophilized product at -20 °C. Following reconstitution, the antibody can be stores at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ROCK2

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Autre désignation: ROCK2 (ROCK2 Produits)

Synonymes: anticorps rocka-a, anticorps xROK, anticorps rock2, anticorps rok2, anticorps ROCK2, anticorps B230113H15Rik, anticorps ROKalpha, anticorps Rho-kinase, anticorps Rock-II, anticorps Rock2m, anticorps mKIAA0619, anticorps ROCK-II, anticorps ROK, anticorps Rho-associated, coiled-coil containing protein kinase 2 L homeolog, anticorps rho-associated, coiled-coil containing protein kinase 2a, anticorps Rho associated coiled-coil containing protein kinase 2, anticorps Rho-associated, coiled-coil containing protein kinase 2, anticorps Rho-associated coiled-coil containing protein kinase 2, anticorps rock2.L, anticorps rock2a, anticorps ROCK2, anticorps Rock2

Sujet: Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24.1 Thumkeo et al. (2003) concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.2Synonyms: KIAA0619, ROCK-2, Rho kinase 2, Rho-associated, Rho-associated protein kinase 2, coiled-coil-containing protein kinase 2, p164ROCK-2

ID gène: 9475

NCBI Accession: NP_004841

UniProt: O75116

Pathways: Dynamique des Microtubules, Signalisation WNT, Tube Formation