Integrin Alpha2b anticorps (Biotin)

N° du produit ABIN119840

Détail du produit anti-Integrin Alpha2b anticorps (Biotin)

Antigène: Integrin Alpha2b (CD41)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin Alpha2b est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Specificité: This antibody recognizes the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo. We recommend the use of SM2035A for use in functional studies.

Purification: Affinity Chromatography on Protein G.

Clone: MWReg30

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry: Neat - 1:10, use 10 μL to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: Phosphate buffered saline containing, pH 7.4 with 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-Integrin Alpha2b (Biotin) (ABIN119840)

Fujita, Takayama-Tsujimoto, Satoh, Gutiérrez, Aburatani, Fujii, Sarai, Bresnick, Yamamoto, Motohashi: "NF-E2 p45 is important for establishing normal function of platelets." dans: Molecular and cellular biology, Vol. 33, Issue 14, pp. 2659-70, (2013) (PubMed).

Takayama, Fujita, Suzuki, Okuyama, Aiba, Motohashi, Yamamoto: "Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis." dans: Molecular and cellular biology, Vol. 30, Issue 11, pp. 2668-80, (2010) (PubMed).

Perez, Desponts, Parquet, Kerr: "SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors." dans: PLoS ONE, Vol. 3, Issue 10, pp. e3565, (2008) (PubMed).

Tamagawa-Mineoka, Katoh, Ueda, Takenaka, Kita, Kishimoto: "The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation." dans: The American journal of pathology, Vol. 170, Issue 6, pp. 2019-29, (2007) (PubMed).

Détails sur Integrin Alpha2b

Antigène: Integrin Alpha2b (CD41)

Autre désignation: CD41 / ITGA2B (CD41 Produits)

Synonymes: anticorps AI172977, anticorps CD41, anticorps CD41B, anticorps GpIIb, anticorps alphaIIb, anticorps BDPLT16, anticorps BDPLT2, anticorps GP2B, anticorps GPIIb, anticorps GT, anticorps GTA, anticorps HPA3, anticorps integrin alpha 2b, anticorps integrin subunit alpha 2b, anticorps Itga2b, anticorps ITGA2B

Sujet: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. CD41 is expressed on platelets and megakaryocytes and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

ID gène: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex