Phospholipase C gamma 1 anticorps

N° du produit ABIN127317

Cet anticorps anti-Phospholipase C gamma 1 Polyclonal Lapin (ABIN127317) détecte spécifiquement Phospholipase C gamma 1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Phospholipase C gamma 1 anticorps (ABIN127317)

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholipase C gamma 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Phospholipase C gamma 1 anticorps

Specificité: The antibody recognizes 139 kDa human PLCγ 1&2.

Purification: Protein A affinity purified

Immunogène: Synthetic peptide surrounding amino acid 1252 of human PLCgamma2

Information d'application

Indications d'application: Western Blot: 0.5-4 μg/mL, Jurkat cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Détails sur Phospholipase C gamma 1

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Autre désignation: PLCG1

Sujet: PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. In response to extracellular stimuli (e.g., hormone, growth factors, neurotransmitters), PLC hydrolizes phosphatidylinositol 4,5-biphosphate (PIP2) into two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLCγ2 is engaged in antigendependent signaling in B-cells and collagen-dependent signaling in platelets.Synonyms: 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma-1, 5-bisphosphate phosphodiesterase gamma-2, PLC-148, PLC-II, PLC-IV, PLC-gamma-1, PLC-gamma-2, PLC1, PLCG-1, PLCG-2, PLCgamma2, Phospholipase C-gamma-1, Phospholipase C-gamma-2

ID gène: 5335

NCBI Accession: NP_877963

UniProt: P19174

Pathways: Signalisation RTK, Signalisation WNT, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling