CD4 anticorps (PE)

N° du produit ABIN133181

Détail du produit anti-CD4 anticorps (PE)

Antigène: CD4

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD4 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: Rat CD4

Purification: Purified from ascitic fluid via Protein G Chromatography.

Immunogène: Rat thymocyte membrane . Fusion Partner: P3-NSI-1-Ag 4 (NSI/1) . Donor: BALB/c spleen

Clone: W3-25

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/ml

Buffer: R-PE conjugated Ig buffered in PBS, 0.02% NaN and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. (Purified from ascitic fluid via Protein G Chromatography).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur CD4

Antigène: CD4

Autre désignation: CD4 (CD4 Produits)

Synonymes: anticorps cd4, anticorps L3T4, anticorps Ly-4, anticorps CD4mut, anticorps W3/25, anticorps p55, anticorps CD4 molecule, anticorps carcinoembryonic antigen-related cell adhesion molecule 5, anticorps T-cell surface glycoprotein CD4, anticorps CD4 antigen, anticorps Cd4 molecule, anticorps CD4, anticorps LOC100125525, anticorps cd4, anticorps Cd4

Sujet: Anti-rat CD4 monoclonal antibody recognizes a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells and peritoneal macrophages. (1,2,3,10.) The antigen recognized by this antibody is a surface glycoprotein of Mr 48,000-52,000 and is the homologue of the human CD4 and the mouse L3/T4 antigen. ABIN133181labels the rat T helper subset, which mediates the helper activity for B and T cells, graft vs. host (GVH) reactivity and produces IL-2 in the mixed lymphocyte reaction (MLR). (2,4,6,). ABIN133181is invaluable for separating T cell subsets for functional studies. It has been used in studying the role of T lymphocytes in graft rejections (7) and in studying the subsets of T cells in the rat which mediate graft vs. host disease .(8) This particular antibody is also one of three antibodies which labels T lymphocyte populations in the rat. These clones include W3/13 ABIN133181, which labels all T cells, as well as MRC OX-8 ABIN133181 and W3/25 ABIN133181 which label non- overlapping T cell subpopulations. These monoclonal antibodies used in concert are being employed extensively to investigate cellular aspects of the immune response in rats and prove to be useful as markers for functionally distinct subpopulations of lymphocytes.

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events