CD40 anticorps (PE)
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- Antigène Voir toutes CD40 Anticorps
- CD40
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD40 est conjugé à/à la PE
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Application
- Flow Cytometry (FACS)
- Specificité
- Mouse CD40
- Immunogène
- mouse CD40-human IgG1 fusion protein
- Isotype
- IgG2a
- Top Product
- Discover our top product CD40 Anticorps primaire
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- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/ml
- Stock
- 4 °C
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- Antigène
- CD40
- Autre désignation
- CD40 (CD40 Produits)
- Synonymes
- anticorps Bp50, anticorps CDW40, anticorps TNFRSF5, anticorps p50, anticorps AI326936, anticorps GP39, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TRAP, anticorps Tnfrsf5, anticorps TNFSF5, anticorps CD40 molecule, anticorps CD40 antigen, anticorps CD40, anticorps Cd40
- Sujet
- Anti-mouse monoclonal antibody (clone 3/23) reacts with CD40 which is ex- pressed on B lymphocytes and on a subset of both CD4 and CD8 T cells in the adult (but not neonatal) spleen . The level of CD40 on B cells is enhanced following activation by LPS . The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal center formation, and generating B cell memory . Stimulat- ing cells with immobilized 3/23 mAb increases expression of CD86 (B7.2) on B cells 1,3 Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3 . Costimulation with 3/23 mAb and IL-4 rescues B cells from apoptosis induced by hypercross-linking of sIgM or sIgD The 3/23 clone is suitable for use in flow cytometry and acetone fixed frozen tissue sec- tions
- Pathways
- Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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