c-MET anticorps

N° du produit ABIN1381745

L’anticorps Rat Monoclonal anti-c-MET a été validé pour FACS et cELISA. Il convient pour détecter c-MET dans des échantillons de Humain.

Aperçu rapide pour c-MET anticorps (ABIN1381745)

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp c-MET est non-conjugé

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: BCI-3E7

Détail du produit anti-c-MET anticorps

Specificité: Anti-human c-Met

Attributs du produit: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding human c-Met

Isotype: IgG2b kappa

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: c-Met

Sujet: C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Single-pass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.

UniProt: P08581

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor