c-MET anticorps (AA 25-150)

N° du produit ABIN671661

Cité dans 5 publications. Cet anticorps anti-c-MET Polyclonal Lapin (ABIN671661) détecte spécifiquement c-MET dans WB, IF, IHC (p) et IHC (fro). L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour c-MET anticorps (AA 25-150) (ABIN671661)

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MET est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-c-MET anticorps

Épitope: AA 25-150

Fonction: MET Polyclonal Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse MET

Isotype: IgG

Information d'application

Indications d'application: WB(1:500-2000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-c-MET (ABIN671661)

Wang, Tang, Shen, Chen, Chen, Luo, Ge: "Hepatocyte growth factor (HGF) optimizes oral traumatic ulcer healing of mice by reducing inflammation." dans: Cytokine, Vol. 99, pp. 275-280, (2018) (PubMed).

Yu, He, Jiang, He, Fan, Wang, Geng, Dong: "Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors." dans: Acta histochemica, (2015) (PubMed).

Li, Zhang, Zhao, Shi, Yao, Zhang, Guo, Liu: "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." dans: Oncology letters, Vol. 9, Issue 5, pp. 1989-1996, (2015) (PubMed).

Gao, Bing, Li, Yang, Li, Chen: "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma." dans: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 546, (2013) (PubMed).

Guo, Yang, Yao, Zhang, Da, Duan: "Expression of MACC1 and c-Met in human gastric cancer and its clinical significance." dans: Cancer cell international, Vol. 13, Issue 1, pp. 121, (2013) (PubMed).

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: Met (c-Met)

Sujet:

Synonyms: MET_HUMAN, Hepatocyte growth factor receptor, EC:2.7.10.1, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor(SF receptor), Tyrosine-protein kinase Met, MET proto-oncogene, receptor tyrosine kinase, DA11, HGFR, AUTS9, RCCP2, c-Met, c Met, DFNB97,

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

ID gène: 4233

UniProt: P16056

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor