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c-MET anticorps (Tyr1003)

MET Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7179985
  • Antigène Voir toutes c-MET (MET) Anticorps
    c-MET (MET) (Met Proto-Oncogene (MET))
    Épitope
    • 49
    • 35
    • 28
    • 21
    • 16
    • 12
    • 11
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Tyr1003
    Reactivité
    • 250
    • 144
    • 98
    • 8
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 221
    • 39
    • 3
    • 2
    Lapin
    Clonalité
    • 209
    • 56
    Polyclonal
    Conjugué
    • 131
    • 20
    • 13
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp c-MET est non-conjugé
    Application
    • 181
    • 104
    • 51
    • 42
    • 30
    • 27
    • 26
    • 24
    • 15
    • 8
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogène
    Synthesized non-phosphopeptide derived from Human c-Met around the phosphorylation site of tyrosine 1003 (V-D-Y(p)-R-A).
    Isotype
    IgG
    Top Product
    Discover our top product MET Anticorps primaire
  • Indications d'application
    WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    c-MET (MET) (Met Proto-Oncogene (MET))
    Autre désignation
    MET (MET Produits)
    Synonymes
    anticorps AUTS9, anticorps HGFR, anticorps RCCP2, anticorps c-Met, anticorps AI838057, anticorps HGF, anticorps Par4, anticorps Hgfr, anticorps c-met, anticorps MET, anticorps C-MET, anticorps met, anticorps met-A, anticorps MET proto-oncogene, receptor tyrosine kinase, anticorps met proto-oncogene, anticorps MET proto-oncogene, receptor tyrosine kinase L homeolog, anticorps MET, anticorps Met, anticorps met.L
    Sujet

    Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

    Hillier L.W., Nature 424:157-164(2003).
    Wang D., J. Biol. Chem. 277:36216-36222(2002).
    Giordano S., Nat. Cell Biol. 4:720-724(2002)

    Aliases: AUTS9 antibody, c met antibody, D249 antibody, Hepatocyte growth factor receptor antibody, HGF antibody, HGF receptor antibody, HGF/SF receptor antibody, HGFR antibody, MET antibody, Met proto oncogene antibody, Met proto oncogene tyrosine kinase antibody, MET proto oncogene, receptor tyrosine kinase antibody, Met proto-oncogene (hepatocyte growth factor receptor) antibody, Met proto-oncogene antibody, Met protooncogene antibody, MET_HUMAN antibody, Oncogene MET antibody, Par4 antibody, Proto-oncogene c-Met antibody, RCCP2 antibody, Scatter factor receptor antibody, SF receptor antibody, Tyrosine-protein kinase Met antibody

    UniProt
    P08581
    Pathways
    Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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