c-MET anticorps (pTyr1349)

N° du produit ABIN389595

Cité dans 2 publications. Cet anticorps anti-c-MET Polyclonal Lapin (Clone RB5215) (ABIN389595) détecte spécifiquement c-MET dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour c-MET anticorps (pTyr1349) (ABIN389595)

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-MET est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5215

Détail du produit anti-c-MET anticorps

Épitope: pTyr1349

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MET Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1349 of human MET.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-c-MET (ABIN389595)

Guo, Reinitz, Youssef, Hong, Nathanson, Akhavan, Kuga, Amzajerdi, Soto, Zhu, Babic, Tanaka, Dang, Iwanami, Gini, Dejesus, Lisiero, Huang, Prins, Wen, Robins, Prados, Deangelis, Mellinghoff, Mehta et al.: "An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. ..." dans: Cancer discovery, Vol. 1, Issue 5, pp. 442-56, (2012) (PubMed).

Guo, Prins, Dang, Kuga, Iwanami, Soto, Lin, Huang, Akhavan, Hock, Zhu, Kofman, Bensinger, Yong, Vinters, Horvath, Watson, Kuhn, Robins, Mehta, Wen, DeAngelis, Prados, Mellinghoff, Cloughesy, Mischel: "EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy." dans: Science signaling, Vol. 2, Issue 101, pp. ra82, (2009) (PubMed).

Détails sur c-MET

Antigène: c-MET (MET) (Met Proto-Oncogene (MET))

Autre désignation: MET

Sujet: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.

Poids moléculaire: 155541

ID gène: 4233

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor