NPC2 anticorps (AA 20-80)

N° du produit ABIN1385817

Détail du produit anti-NPC2 anticorps

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Épitope: AA 20-80

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Niemann Pick C2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NPC2

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Autre désignation: NPC2/Niemann Pick C2 (NPC2 Produits)

Synonymes: anticorps 2700012J19Rik, anticorps AA408070, anticorps AU045843, anticorps HE1, anticorps EDDM1, anticorps re1, anticorps CE1, anticorps EPI-1, anticorps cb292, anticorps sb:cb292, anticorps NPC intracellular cholesterol transporter 2, anticorps Niemann-Pick disease, type C2, anticorps Npc2, anticorps NPC2, anticorps npc2

Sujet:

Synonyms: EDDM1, Epididymal protein 1, Epididymal secretory protein, Epididymal secretory protein E1, HE1, Human epididymis-specic protein 1, Niemann-Pick disease type C2, Niemann-Pick disease type C2 protein, NPC2, NPC2_HUMAN, Tissue specic secretory protein.

Background: NPC2 is a secreted protein mapping against gene 14q24.3 (1,2). NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis(1,2). Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1,2,3). Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol (3). The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients (3). This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present (3).

Pathways: SARS-CoV-2 Protein Interactome