NPC2 anticorps (N-Term)
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- Antigène Voir toutes NPC2 Anticorps
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NPC2 est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- NPC2 Antibody detects endogenous levels of total NPC2.
- Homologie
- Horse,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human NPC2, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product NPC2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- Autre désignation
- NPC2 (NPC2 Produits)
- Synonymes
- anticorps 2700012J19Rik, anticorps AA408070, anticorps AU045843, anticorps HE1, anticorps EDDM1, anticorps re1, anticorps CE1, anticorps EPI-1, anticorps cb292, anticorps sb:cb292, anticorps NPC intracellular cholesterol transporter 2, anticorps Niemann-Pick disease, type C2, anticorps Npc2, anticorps NPC2, anticorps npc2
- Sujet
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Description: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Gene: NPC2
- Poids moléculaire
- 17kDa
- ID gène
- 10577
- UniProt
- P61916
- Pathways
- SARS-CoV-2 Protein Interactome
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