NPC2 anticorps (AA 20-151)

N° du produit ABIN7161731

Détail du produit anti-NPC2 anticorps

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Épitope: AA 20-151

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human NPC intracellular cholesterol transporter 2 protein (20-151AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NPC2

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Autre désignation: NPC2 (NPC2 Produits)

Synonymes: anticorps 2700012J19Rik, anticorps AA408070, anticorps AU045843, anticorps HE1, anticorps EDDM1, anticorps re1, anticorps CE1, anticorps EPI-1, anticorps cb292, anticorps sb:cb292, anticorps NPC intracellular cholesterol transporter 2, anticorps Niemann-Pick disease, type C2, anticorps Npc2, anticorps NPC2, anticorps npc2

Sujet:

Background: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Aliases: EDDM1 antibody, Epididymal protein 1 antibody, Epididymal secretory protein antibody, Epididymal secretory protein E1 antibody, hE1 antibody, Human epididymis-specific protein 1 antibody, Niemann-Pick disease type C2 antibody, Niemann-Pick disease type C2 protein antibody, NPC intracellular cholesterol transporter 2 antibody, NPC2 antibody, NPC2_HUMAN antibody, Tissue specific secretory protein antibody

UniProt: P61916

Pathways: SARS-CoV-2 Protein Interactome