PIN1 anticorps (AA 50-100)

N° du produit ABIN1574018

Détail du produit anti-PIN1 anticorps

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Épitope: AA 50-100

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Rabbit Anti-PIN1 Polyclonal Antibody detects human PIN1 protein. Sequence homology predicts that it will also react with rat and mouse PIN1 proteins.

Réactivité croisée (Details): Rabbit Anti-PIN1 Polyclonal Antibody detects human PIN1 protein. Sequence homology predicts that it will also react with rat and mouse PIN1 proteins.

Purification: Immunoaffinity chromatography

Immunogène: Synthetic peptide (KLH-coupled) within AA 50-100 of human PIN1 protein

Isotype: IgG

Information d'application

Indications d'application: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

ELISA: 0.05-0.2 µg/mL
Western blot: 0.5-1 µg/mL
Other applications: user-optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C/-20 °C

Stockage commentaire: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Détails sur PIN1

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Autre désignation: PIN1 (PIN1 Produits)

Synonymes: anticorps DOD, anticorps UBL5, anticorps dod, anticorps ubl5, anticorps pin1, anticorps pin1a, anticorps 0610025L01Rik, anticorps D9Bwg1161e, anticorps pin1b, anticorps zgc:73206, anticorps PPIase pin1, anticorps MdPin1, anticorps Pin1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog, anticorps protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, anticorps peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog, anticorps peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, anticorps peptidyl-prolyl cis-trans isomerase Pin1, anticorps PIN1, anticorps Pin1, anticorps pin1, anticorps pin1.S, anticorps pin1.L, anticorps ppiD, anticorps PITG_11123, anticorps LOC103419188

Sujet: PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity. It displays a preference for an acidic residue N-terminal to the isomerized proline bond. It catalyzes pSer/Thr-Pro cis/trans isomerizations. PIN1 has been implicated in tau pathologies that underlie Alzheimer's disease. PIN1 binds to tau-phosphorylated sites, specifically on the Thr231-Pro site, where it induces conformational changes. PIN1 may be pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration.Rabbit Anti-PIN1 Polyclonal Antibody is developed in rabbit hosts using a KLH-coupled synthetic peptide within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526).