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SETD2 anticorps (AA 803-1103)
SETD2
Reactivité: Humain
WB, IF
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN1682666
Détail du produit anti-SETD2 anticorps
(cache)
Antigène
Voir toutes SETD2 Anticorps
SETD2
(SET Domain Containing 2 (SETD2))
Épitope
Tous les épitopes à travers SETD2 Anticorps.
AA 803-1103
Reactivité
Toutes les réactivités sur SETD2 Anticorps
Humain
Hôte
Toutes les hôtes sur SETD2 Anticorps
Lapin
Clonalité
Toutes les clonalités sur SETD2 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers SETD2 Anticorps
Cet anticorp SETD2 est non-conjugé
Application
Tous les applications à travers SETD2 Anticorps.
Western Blotting (WB), Immunofluorescence (IF)
Séquence
SLCNSEAENI EPSVMKISSN SFMNVHLESK PVICDSRNLT DHSKFACEEY KQSIGSTSSA SVNHFDDLYQ PIGSSGIASS LQSLPPGIKV DSLTLLKCGE NTSPVLDAVL KSKKSSEFLK HAGKETIVEV GSDLPDSGKG FASRENRRNN GLSGKCLQEA QEEGNSILPE RRGRPEISLD ERGEGGHVHT SDDSEVVFSS CDLNLTMEDS DGVTYALKCD SSGHAPEIVS TVHEDYSGSS ESSNDESDSE DTDSDDSSIP RNRLQSVVVV PKNSTLPMEE TSPCSSRSSQ SYRHYSDHWE D
Réactivité croisée
Humain, Souris, Rat
Attributs du produit
Polyclonal Antibodies
Immunogène
Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).
Isotype
IgG
Alternatives
(show)
Information d'application
(cache)
Indications d'application
WB,1:500 - 1:2000,IF,1:50 - 1:200
Restrictions
For Research Use only
Stockage
(cache)
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store at -20°C. Avoid freeze / thaw cycles.
Références pour anticorps anti-SETD2 (ABIN1682666)
(cache)
Huang, Gu, Li : "H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation. " dans: The Journal of biological chemistry , Vol. 293 , Issue 20 , pp. 7811-7823 , (2019 ) (PubMed ).
Jia, Long, Miron, Yin, Wei, Zhang, Wu : "Setd2 is associated with strontium-induced bone regeneration. " dans: Acta biomaterialia , Vol. 53 , pp. 495-505 , (2018 ) (PubMed ).
Chen, Liu, Liu, Xia, Zhang, Han, Jiang, Wang, Cao : "Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity. " dans: Cell , Vol. 170 , Issue 3 , pp. 492-506.e14 , (2017 ) (PubMed ).
Zhu, Lei, Ju, Wang, Huang, Yang, Shao, Zhu, Wei, Fu, Li, Wu : "SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. " dans: Nucleic acids research , Vol. 45 , Issue 1 , pp. 92-105 , (2017 ) (PubMed ).
Détails sur SETD2
(cache)
Antigène
SETD2
(SET Domain Containing 2 (SETD2))
Autre désignation
SETD2 (SETD2 Produits )
Synonymes
anticorps Kif9, anticorps HBP231, anticorps HIF-1, anticorps HIP-1, anticorps HYPB, anticorps KMT3A, anticorps SET2, anticorps p231HBP, anticorps SET domain containing 2, anticorps Setd2, anticorps SETD2
Sujet
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.,SETD2,HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,p231HBP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD2
Poids moléculaire
175 kDa/192 kDa/287 kDa
ID gène
29072
UniProt
Q9BYW2
Pathways
Tube Formation
Vus récemment
(cache)