FGF1 anticorps

N° du produit ABIN1685162

Détail du produit anti-FGF1 anticorps

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Polyclonal acidic FGF antibody was produced from sera of rabbits immunized with synthetic protein containing aFGF antigenic determinants.

Isotype: IgG

Information d'application

Indications d'application: ELISA: Use at a concentration range of 1-2 µg/mL.
Western blot: A suitable range of concentrations of this antibody for WB detection is 10 µg/mL.
IHC: A suitable range of concentrations of this antibody for IHC is 10 µg/mL.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers

Buffer: PBS solution at a concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Recombinant CD48, as supplied, can be stored in working aliquots at - 8 °C for one month, or at -20 °C to -70 °C for twelve months.

Date de péremption: 12 months

Détails sur FGF1

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Autre désignation: aFGF (FGF1 Produits)

Synonymes: anticorps AFGF, anticorps ECGF, anticorps ECGF-beta, anticorps ECGFA, anticorps ECGFB, anticorps FGF-1, anticorps FGF-alpha, anticorps FGFA, anticorps GLIO703, anticorps HBGF-1, anticorps HBGF1, anticorps Fgf1, anticorps FGF1, anticorps aFGF, anticorps ecgf, anticorps fgfa, anticorps ecgfa, anticorps ecgfb, anticorps fgf-1, anticorps hbgf1, anticorps glio703, anticorps ecgf-beta, anticorps fgf-alpha, anticorps Dffrx, anticorps Fam, anticorps Fgf-1, anticorps Fgfa, anticorps zgc:136885, anticorps LOC100221393, anticorps fgf1, anticorps zgc:73249, anticorps fibroblast growth factor 1, anticorps fibroblast growth factor 1 L homeolog, anticorps fibroblast growth factor 1b, anticorps fibroblast growth factor 1a, anticorps FGF1, anticorps fgf1.L, anticorps fgf1, anticorps Fgf1, anticorps fgf1b, anticorps LOC100221393, anticorps fgf1a

Sujet: CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for B4. CD48/2B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk. The absence of functional B4/CD48 interactions impairs NK cell cytotoxic response and IFN- release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by aB4/CD48-dependent mechanism.

UniProt: P05230

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway