LCP2 anticorps (pTyr145)

N° du produit ABIN1713568

Détail du produit anti-LCP2 anticorps

Antigène: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Épitope: pTyr145

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LCP2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLP76 (Tyr145)

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur LCP2

Antigène: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Autre désignation: SLP76 (LCP2 Produits)

Synonymes: anticorps AI323664, anticorps BB161688, anticorps SLP-76, anticorps SLP76, anticorps twm, anticorps Slp76, anticorps lymphocyte cytosolic protein 2, anticorps Lcp2, anticorps LCP2

Sujet:

Synonyms: SLP76 phospho Y145, p-SLP76 Y145, p-LCP2, 76 kDa tyrosine phosphoprotein, CG8697, LCP 2, LCP 2, LCP2, LCP2_HUMAN, Lymphocyte Cytosolic Protein 2, Lymphocyte Cytosolic Protein 2, SH2 Domain Containing Leukocyte Protein 76 KD, SH2 domain containing leukocyte protein of 76kD, SH2 domain containing leukocyte protein of 76 kDa, SH2 domain-containing leukocyte protein of 76 kDa, SLP 76, SLP 76, SLP 76 tyrosine phosphoprotein, SLP-76 tyrosine phosphoprotein, SLP76, SLP76 tyrosine phosphoprotein.

Background: The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav?s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway