ABCB1 anticorps (AA 632-693)
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- Antigène Voir toutes ABCB1 Anticorps
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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Épitope
- AA 632-693
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ABCB1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human ABCB1 (AA: 632-693) expressed in E. coli.
- Clone
- 6G11C12
- Isotype
- IgG1
- Top Product
- Discover our top product ABCB1 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." dans: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, (2013) (PubMed).
: "Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells." dans: Journal of cancer research and therapeutics, Vol. 8, Issue 2, pp. 226-31, (2012) (PubMed).
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Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." dans: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, (2013) (PubMed).
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- Antigène
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Autre désignation
- ABCB1 (ABCB1 Produits)
- Synonymes
- anticorps ABC20, anticorps CD243, anticorps CLCS, anticorps GP170, anticorps MDR1, anticorps P-GP, anticorps PGY1, anticorps Abcb1, anticorps Mdr1a, anticorps p-gp, anticorps xemdr, anticorps Mdr1, anticorps Mdr1b, anticorps Pgy-1, anticorps Pgy1, anticorps mdr, anticorps ABCB1, anticorps PGP1, anticorps ATP binding cassette subfamily B member 1, anticorps ATP binding cassette subfamily B member 1A, anticorps ATP binding cassette subfamily B member 1 L homeolog, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 1B, anticorps ABCB1, anticorps Abcb1a, anticorps abcb1.L, anticorps Abcb1b, anticorps Abcb1
- Sujet
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Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ,
Aliases: CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170
- Poids moléculaire
- 141.5 kDa
- ID gène
- 5243
- HGNC
- 5243
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