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TNFRSF10B anticorps (AA 388-407)
TNFRSF10B
Reactivité: Humain, Souris
WB, ICC, IHC (p), IF
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN1733770
Détail du produit anti-TNFRSF10B anticorps
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Antigène
Voir toutes TNFRSF10B Anticorps
TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Épitope
Tous les épitopes à travers TNFRSF10B Anticorps.
AA 388-407
Reactivité
Toutes les réactivités sur TNFRSF10B Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur TNFRSF10B Anticorps
Lapin
Clonalité
Toutes les clonalités sur TNFRSF10B Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers TNFRSF10B Anticorps
Cet anticorp TNFRSF10B est non-conjugé
Application
Tous les applications à travers TNFRSF10B Anticorps.
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificité
Reacts with human and mouse DR5.
Purification
Purified
Immunogène
Synthetic peptide corresponding to aa 388- 407 of human DR5 precursor (accession no.AF012535)
Isotype
IgG
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Information d'application
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Indications d'application
Working dilution: Optimal dilution should be determined by the end user. The following are guidelines only: WB(2 μg/mL) ICC(5 μg/mL)
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS, pH 7.4
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Dilute in PBS or medium which is identical to that used in the assay system.
Stock
-20 °C
Stockage commentaire
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Détails sur TNFRSF10B
(cache)
Antigène
TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Autre désignation
DR5 (TNFRSF10B Produits )
Synonymes
anticorps TNFRSF10B, anticorps dr5, anticorps cd262, anticorps killer, anticorps trick2, anticorps trickb, anticorps xDR-M1, anticorps xDR-M2, anticorps ztnfr9, anticorps trailr2, anticorps trick2a, anticorps trick2b, anticorps CD262, anticorps DR5, anticorps KILLER, anticorps KILLER/DR5, anticorps TRAIL-R2, anticorps TRAILR2, anticorps TRICK2, anticorps TRICK2A, anticorps TRICK2B, anticorps TRICKB, anticorps ZTNFR9, anticorps Ly98, anticorps MK, anticorps tumor necrosis factor receptor superfamily, member 10b, anticorps tumor necrosis factor receptor superfamily member 10b S homeolog, anticorps tumor necrosis factor receptor superfamily member 10b L homeolog, anticorps tumor necrosis factor receptor superfamily member 10b, anticorps TNF receptor superfamily member 10b, anticorps Tnfrsf10b, anticorps TNFRSF10B, anticorps tnfrsf10b.S, anticorps tnfrsf10b.L, anticorps tnfrsf10b
Sujet
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family. A novel death domain containing receptor for TRAIL was recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several independent laboratories. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Tumor necrosis factor receptor superfamily member 10B Death receptor 5 TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2 CD_antigen: CD262 KILLER/DR5,TRICK2A, TRICK2B, TRICKB Gene name: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
ID gène
8795
UniProt
O14763
Pathways
Signalisation p53 , Apoptose , Positive Regulation of Endopeptidase Activity
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